Juntendo University · Graduate School of Medicine / Faculty of Medicine · 准教授

Research keywordsユビキチン・タンパク質分解・プロテアソーム・オートファジー

Research fieldsMolecular biology・Functional biochemistry

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• Endo A*, Fukushima T, Takahashi C, Tsuchiya H, Ono S, Ly T, Yoshida Y, Tanaka K, Saeki Y*, Komada M*. USP8 prevents aberrant NF-kB and Nrf2 activation by counteracting ubiquitin signals from endosomes. J. Cell Biol., 223, 20242024
• Tsunoda, T., Riku, N. Yamada, N., Tsuchiya, H., Tomita, T., Suzuki, M., Kizuki, M., Inoko, A., Ito, H., Murotani, K., Murakami, H., Saeki, Y., and Kasai, K. ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer. EMBO Rep. e51182 , 20212021
• *Yasuda S, * Tsuchiya, H. (* co-1st author), *Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernandez-Busnadiego R, Tanaka K, Saeki Y. Stress- and ubiquitylation-dependent phase separation of the proteasome. Nature 578, 296-300, 20202020
• *Sato Y, *Tsuchiya, H. (* co-1st author), Yamagata A, Okatsu K, Tanaka, K, Saeki Y, Fukai S. Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4. Nat. Commun. 10, 5709 （2019）2019

• プロテアソーム結合ユビキチンリガーゼによるタンパク質分解制御
• 哺乳類個体を用いた非定型ユビキチン鎖の機能解析
• EGF受容体および不良ミトコンドリアにおけるユビキチン修飾の実体解明
• 分岐型ユビキチン鎖が司る新たなシグナル伝達機構

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