Juntendo University · Graduate School of Medicine / Faculty of Medicine

Research keywordsmetastatic hormone-sensitive prostate cancer・abiraterone・combined androgen blockade・radiation-induced bladder cancer・prostate brachytherapy・cutaneous angiosarcoma・urologic oncology

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• Protein farnesylation in mammalian cells: effects of farnesyltransferase inhibitors on cancer cells.
• Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis
• Expression of an oncogenic mutant G alpha i2 activates Ras in Rat-1 fibroblast cells
• Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon

• 紫外線による皮膚発癌、皮膚炎症、白内障及び乾癬におけるホスホリパーゼＣεの役割
• 発癌における炎症とホスホリパーゼＣεの機能の解明
• 低分子量G蛋白質のクロストークを仲介するRap1活性化因子の機能解析
• 低分子量G蛋白質による細胞増殖の制御機構

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