Juntendo University · Graduate School of Medicine / Faculty of Medicine · 准教授

Research keywords消化器科・炎症性腸疾患・クローン病・大腸癌・小腸疾患・消化器内視鏡・潰瘍性大腸炎・Janus kinase inhibitors・fecal microbiota transplantation

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• Hojo M, Ueda K, Ueyama H, Takeda T, Oki S, Abe D, Nomura K, Murakami T, Ishikawa D, Shimada Y, Asaoka D, Okahara R, Nojiri S, Shibuya T, Nagahara A. Immediate discontinuation versus gradual tapering of proton pump inhibitors in long-term users: a randomized controlled trial. J Gastroenterol. 2026 Apr 27. doi: 10.1007/s00535-026-02419-z. Epub ahead of print. PMID: 42043530.2026
• Yano S, Osada T, Ogiwara S, Furihata M, Hattori K, Heissig B, Nomura O, Shibuya T, Nagahara A. Predicting Clinical Response to Granulocyte/Monocyte Adsorption Apheresis in Treatment-Resistant Ulcerative Colitis. Gastro Hep Adv. 2026 Mar 14;5(6):100922. doi: 10.1016/j.gastha.2026.100922. PMID: 42027701; PMCID: PMC13101580.2026
• Omori M, Shibahara K, Murakami T, Kamba E, Nomura K, Fukushima H, Ishikawa D, Hojo M, Shibuya T, Nagahara A. Incidental Detection of Asymptomatic Colonic Anisakiasis During Surveillance Colonoscopy: A Case Report and Literature Review. Clin Case Rep. 2026 Apr 24;14:e72593. doi: 10.1002/ccr3.72593. PMID: 42040387; PMCID: PMC13107408.2026
• Shibuya T, Ito K, Omori M, Odakura R, Koma M, Nomura K, Murakami T, Ueda K, Ishikawa D, Hojo M, Nagahara A. Recurrent local and systemic hypersensitivity reactions after switching back from subcutaneous to intravenous vedolizumab in ulcerative colitis: a case presentation. Gastroenterol Rep (Oxf). 2026 May 16;14:goag048. doi: 10.1093/gastro/goag048. PMID: 42170215; PMCID: PMC13187746.2026

• 酸化ストレス応答アポトーシス誘導蛋白のUCに対する新規Biomarker探索と治療への展開
• 内視鏡・病理組織学的所見、腸内細菌叢動態、腸管免疫変化の網羅的解析による喫煙が潰瘍性大腸炎病態に及ぼす因子の抽出
• 大腸癌関連線維芽細胞の癌悪性化および治療抵抗性促進機構の解明と新規治療への応用

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