Juntendo University · Graduate School of Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences · 教授

Research keywordsenantioselective synthesis・lipase catalyzed kinetic resolution・atroposelective coupling・spirocyclobutane synthesis・intramolecular Diels Alder reactions・stereoselective annulation

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• Lipase-Catalyzed Kinetic Resolution Followed by an Intramolecular Diels–Alder Reaction: Enantio- and Diastereoselective Synthesis of an A-Ring Moiety of Furanosteroids Chiharu Yuki, Shuhei Hori, Satoshi Horino, Hiroshi Aoyama, Kyohei Kanomata, Shuji Akai Chem. Pharm. Bull. (2025) 73(8), 663–669 DOI: 10.1248/cpb.c25-002382025
• Total Synthesis of (±)-Minimiflorin and Its Na+/K+-ATPase and H+/K+-ATPase Inhibitory Activities Wataru Yamawaki, Kuniaki Suzuki, Yuri Hase, Hiroshi Aoyama, Atsushi Nakayama, Makoto Sako, Mitsuhiro Arisawa Journal of Natural Products (2025) DOI: 10.1021/acs.jnatprod.5c004632025
• Size-selective permeation-enhancing modulation of the tight junction by receptor-binding domains of Clostridium perfringens enterotoxin and Clostridium perfringens iota-toxin. Keisuke Tachibna, Sayaka Sugimura, Shuko Sakimura, Lin Bai, Hiroshi Aoyama, Hiroyuki Takeda, Yuki Niwa, Masahiro Nagahama, Masuo Kondoh Tissue Barriers (2025) DOI: 10.1080/21688370.2025.24599632025
• Controlling (E/Z)-Stereoselectivity of -NHC=O Chlorination: Mechanism Principles for Wide Scope Applications Raed M. Maklad, Gamal A. I. Moustafa, Hiroshi Aoyama, Abdullah A. Elgazar Chem. Eur J. (2024), 30, e202400785 DOI: 10.1002/chem.2024007852024

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