Juntendo University · Graduate School of Medicine / Faculty of Medicine

Research keywordsosteosarcoma molecular targets・ROS1 fusion genes・sarcoma genomics・tyrosine kinase aberrations・NanoString screening

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• PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma.
• Identification of a NovelMAN1A1-ROS1Fusion Gene Through mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a Patient with Leiomyosarcoma
• Establishment of Rapid and Accurate Screening System for Molecular Target Therapy of Osteosarcoma.

• 膵胆管好酸性乳頭状腫瘍における融合遺伝子の作用機序解明と診断・治療法への展開
• 骨巨細胞腫のバイオマーカー・治療標的の開発と機能解析
• 「希少がん」軟部肉腫のキナーゼ阻害剤著効症例に基づいた新規治療法の開発
• 胃底腺型胃癌発生におけるWnt系・Hedgehog系とGNAS遺伝子変異の関与

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