Juntendo University · Graduate School of Medicine / Faculty of Medicine · 教授

Research keywordsthalamocortical projections・motor thalamic nuclei・inhibitory neuronal subtypes・excitatory neuronal subtypes・sleep homeostasis in lizards・AAV vector tracing・multiplex immunofluorescence・tyramide signal amplification

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• *Yamauchi K, Koike M, *Hioki H. (2025) A protocol for multiplex immunofluorescence staining with a fluorescent tyramide signal amplification system, FT-GO. Anat Sci Int. Online ahead of print. PMID:40372591, doi:10.1007/s12565-025-00846-12025
• *Ageta-Ishihara N, Fukazawa Y, Arima-Yoshida F, Okuno H, Ishii Y, Takao K, Konno K, Fujishima K, Ageta H, Hioki H, Tsuchida K, Sato Y, Kengaku M, Watanabe M, Watabe AM, Manabe T, Miyakawa T, Inokuchi K, Bito H, *Kinoshita M. (2025) Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines. Cell Rep. 44(3):115352. PMID:40023151, doi:10.1016/j.celrep.2025.1153522025
• *Matsushima SK, Shimada Y, Kinoshita M, Nagashima T, Okamoto S, Iizuka S, Takagi H, Iizuka S, Higuchi T, Hioki H, Watabe AM, Sonoda H, Ohashi T, Kobayashi H. (2025) Adeno-associated virus expressing a blood-brain barrier–penetrating enzyme improves GM1 gangliosidosis in a preclinical model. J Clin Invest. 135(12):e180724. PMID:40198143, doi:10.1172/JCI1807242025
• *Yamauchi K, Koike M, *Hioki H. (2025) A Three Dimensional Immunolabeling Method with Peroxidase-fused Nanobodies and Fluorochromized Tyramide-Glucose Oxidase Signal Amplification. Commun Biol. 8(1):903. PMID:40533487, doi:10.1038/s42003-025-08317-z2025

• オートファジーに関する学際的研究：動作原理から病態生理まで
• レンチウイルスベクターによる視床-大脳新皮質相互結合の定量的解析
• 機能性オルガノイドを用いた運動ニューロン疾患遺伝子治療薬スクリーニング系の確立
• アデノ随伴ウイルスキャプシドタンパク改変による新規感染指向性の獲得

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