Kagoshima University · Graduate School of Medical and Dental Sciences

Research keywordsendoscopic submucosal dissection・gastric cancer・esophageal ulcer healing・wound healing biomaterials・traction techniques・perirectal abscess

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• Maeda H., Sasaki F., Sakae T., Tanaka A., Kanmura S., Tamai T., Ido A. . A case of early gastric cancer with esophagogastric varices safely treated with endoscopic submucosal dissection after2024 · 記述言語： 日本語 出版者・発行元： VideoGIE DOI： 10.1016/j.vgie.2024.03.009 Scopus
• Iwata Hiroki, Maeda Hidehito, Tsuneyoshi Kengo, Matsumoto Takuma, Fujita Hiroshi, Komohara Yoshihiro, Ido Akio2024 · 記述言語： 英語 出版者・発行元： John Wiley & Sons Australia, Ltd
• Fujino Y, Kanmura S, Morinaga Y, Kojima I, Maeda N, Tanaka A, Maeda H, Kumagai K, Sasaki F, Tanoue S, Ido A . Hepatocyte growth factor ameliorates dextran sodium sulfate‑induced colitis in a m2023 · 記述言語： 英語 出版者・発行元： Molecular Medicine Reports Hepatocyte growth factor (HGF) serves key roles in cell motility, proliferation and immunoregulatory functions. However, the effect of HGF on macrophages is unclear. The present study aimed to elucidate the effect of HGF on the pheno- typic alterations of intestinal lamina propria mononuclear cells (LPMCs). Colitis was induced in a mouse model using dextran sodium sulfate (DSS). Subsequently, LPMCs were isolated from the mice with chronic colitis and the expression levels of cytokine-encoding genes in the LPMCs were determined. CD11b-positive macrophages isolated from LPMCs were cultured with HGF, and alterations in the levels of M1 or M2 markers were evaluated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and flow cytometry. In addition, the cytokine levels were assessed using RT-qPCR and ELISA. HGF shifted the phenotype of macrophages from M1 to M2-like, as determined by increased mRNA expression levels of arginase-1, CD206 and IL-10, and reduced mRNA expression levels of CD86 and IL-6 in mice with DSS-induced colitis. Moreover, HGF could ameliorate DSS-induced colitis owing to its immunosuppressive effect on immune cells. These findings indicated that HGF treatment may not only promote the regeneration of epithelial cells but also lead to tissue repair by phenotypic alteration of M1 macrophages to M2-like macrophages. DOI： 10.3892/mmr.2023.12957 Scopus PubMed
• Sasaki Fumisato, Mawatari Seiichi, Oda Kohei, Yano Hiroki, Maeda Hidehito, Tanaka Akihito, Arima Shiho, Kumagai Kotaro, Tanoue Shiroh, Hashimoto Shinichi, Kanmura Shuji, Ido Akio2023 · 記述言語： 英語 出版者・発行元： シュプリンガー・ジャパン(株)

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