Kagoshima University · Medical Care Center

Research keywordsperitoneal fibrosis・diabetic kidney disease・hemodialysis complications・vascular access intervention・renal risk prediction・Fabry disease screening

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• Minami Masato, Mizuma Emiko, Nakahara Mai, Oda Yumi, Yoshimine Haruhito, Tokunaga Koki, Mitsuke Akihiko, Yamada Yasutoshi, Enokida Hideki, Masutani Kosuke, Goto Norihiko, Ido Akio2021 · 記述言語： 英語 出版者・発行元： シュプリンガー・ジャパン(株)
• DKDとNAFLD2021 · 医学出版 2021年6月
• バスキュラーアクセス閉塞からvascular access intervention therapyまでの期間の検討2013 · 東京医学社 2013年1月
• Kawasoe S., Kubozono T., Salim A.A., Yoshimine H., Mawatari S., Ojima S., Kawabata T., Ikeda Y., Miyahara H., Tokushige K., Ido A., Ohishi M. . Development of a risk prediction score and equat記述言語： 日本語 出版者・発行元： Scientific Reports Chronic kidney disease (CKD) is a risk factor for end-stage renal disease and contributes to increased risk of cardiovascular disease morbidity and mortality. We aimed to develop a risk prediction score and equation for future CKD using health checkup data. This study included 58,423 Japanese participants aged 30–69 years, who were randomly assigned to derivation and validation cohorts at a ratio of 2:1. The predictors were anthropometric indices, life style, and blood sampling data. In derivation cohort, we performed multivariable logistic regression analysis and obtained the standardized beta coefficient of each factor that was significantly associated with new-onset CKD and assigned scores to each factor. We created a score and an equation to predict CKD after 5 years and applied them to validation cohort to assess their reproducibility. The risk score ranged 0–16, consisting of age, sex, hypertension, dyslipidemia, diabetes, hyperuricemia, and estimated glomerular filtration rate (eGFR), with area under the curve (AUC) of 0.78 for the derivation cohort and 0.79 for the validation cohort. The CKD incidence gradually and constantly increased as the score increased from ≤ 6 to ≥ 14. The equation consisted of the seven indices described above, with AUC of 0.88 for the derivation cohort and 0.89 for the validation cohort. We developed a risk score and equation to predict CKD incidence after 5 years in Japanese population under 70 years of age. These models had reasonably high predictivity, and their reproducibility was confirmed through internal validation. DOI： 10.1038/s41598-023-32279-z Scopus PubMed

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