Kagoshima University · Graduate School of Medical and Dental Sciences

Research keywordsGastroenterology・Internal・medicine・Immunology・Inflammatory・bowel・disease・Inflammation

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• Fujino Y, Kanmura S, Morinaga Y, Kojima I, Maeda N, Tanaka A, Maeda H, Kumagai K, Sasaki F, Tanoue S, Ido A.2023 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌）
• Akihito Tanaka 1 , Shuji Kanmura 1 , Yuko Morinaga 1 , Katsuto Kawabata 1 , Shiho Arima 1 , Fumisato Sasaki 1 , Yuichirou Nasu 1 , Shiroh Tanoue 1 , Shinichi Hashimoto 1 , Masahiko Takeshita 2 , Shiro2020 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） Dysbiosis of the enteric microbiota causes gastrointestinal diseases, including colitis. The present study investigated the beneficial effect of Lactobacillus plantarum 06CC2 in experimental colitis in mice. An experimental colitis model in C57BL6 mice was induced using dextran sulfate sodium. Mice were orally administered 06CC2 (06CC2 group) or PBS only (control group) by gavage. The disease activity index (DAI), histological grading, and colon tissue and colonic lamina propria mononuclear cells (LPMCs) were examined macroscopically and histopathologically, and the expression levels of inflammation‑associated cytokines (IL‑6, IL‑12, TNF‑α and IL‑10) in these samples were determined. Compared with the control group, the 06CC2 group exhibited a significantly lower DAI (1.5±0.8 vs. 0.2±0.3, respectively; P<0.05) and pathology score (6.3±1.5 vs. 3.8±1.3, respectively; P<0.05). IL‑10 expression in colonic LPMCs was higher in the 06CC2 group than in the control group, although there was no significant difference in IFN‑γ, IL‑6 or IL‑12 expression in colonic LPMCs between the two groups. In addition, 06CC2 stimulated the production of IL‑10 from CD11b‑positive cells and CD11c‑positive cells in the colon. The 06CC2 strain induced IL‑10 production in the colon and attenuated colon inflammation. DOI： 10.3892/mmr.2020.10925 PubMed
• Nishikoba N, Kumagai K, Kanmura S, Nakamura Y, Ono M, Eguchi H, Kamibayashiyama T, Oda K, Mawatari S, Tanoue S, Hashimoto S, Tsubouchi H, Ido A . HGF-MET Signaling Shifts M1 Macrophages2020 · DOI： 10.3389/fimmu.2020.02135 PubMed
• Kawabata K, Kanmura S, Morinaga Y, Tanaka A, Makino T, Fujita T, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Ido A . A high‑fructose diet induces epithelial barrier dysfunction an2018 · DOI： 10.3892/ijmm.2018.4040 PubMed

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