Kagoshima University · Medical Care Center

Research keywords医学・歯学・薬学・保健

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• Mitsuyama H., Iizasa E., Kukita A., Toda S., Yoshida H., Inoue H., Hara H. . Deletion of Card9 eliminates the detrimental facets of mycobacterial adjuvants . Heliyon10 (2024 · 記述言語： 日本語 出版者・発行元： Heliyon Although mycobacterial adjuvants are capable of eliciting a strong adaptive humoral and cellular immunity, they also sometimes provoke detrimental outcomes, including autoimmune/inflammatory syndromes. Here, we show that the deletion of caspase recruitment domain family member 9 (Card9), a signaling adaptor of a set of innate immune receptors, can eliminate the detrimental effects of mycobacterial adjuvants. Long-lasting tissue-destructive skin inflammation at the site of complete Freund's adjuvant (CFA) injection, lung granuloma formation induced by intratracheal Mycobacterium bovis Bacillus Calmette-Guérin infection, and the incidence and severity of experimental autoimmune encephalomyelitis and collagen-induced arthritis induced by autoantigen immunization with CFA were considerably attenuated in Card9-deficient (Card9−/−) mice compared to control wild-type mice. Card9−/− mice showed impaired development of Th17, but not Th1, in the early phase after autoimmune induction, due to the impaired development of IL-6-producing Sirpαhigh dendritic cells, which are essential for priming pathigenic Th17, in the draining lymph nodes. However, Card9 deletion did not affect overall adaptive antibody production or delayed-type hypersensitivity following immunization with CFA, indicating that humoral and type 1 immune responses remained intact. These results suggest that avoiding the activation of Card9 signaling during vaccination with mycobacteria-containing vaccines may mitigate the risk of detrimental type 3 immune responses, while preserving type 1 immune responses that are effective against intracellular pathogens and cancers. DOI： 10.1016/j.heliyon.2024.e38139 Scopus
• 里村 緑, 美園 俊祐, 米 未紀子, 冨岡 勇也, 大脇 一人, 松山 崇弘, 高木 弘一, 三山 英夫, 末次 隆行, 井上 博雅2022 · 記述言語： 日本語 出版者・発行元： (一社)日本結核・非結核性抗酸菌症学会
• 隈元 朋洋, 井上 博雅, 冨岡 勇也, 松山 洋美, 鵜木 泰自, 谷川 健悟, 堂嶽 洋一, 三山 英夫, 籾 博晃, 佐藤 雅美 . 若年男性に発症した気管支原発粘表皮癌の1例 . 気管支学41 ( 2 ) 193 - 197 2019年 詳2019 · 出版者・発行元： 特定非営利活動法人 日本呼吸器内視鏡学会 <p><b>背景．</b>気管支原発粘表皮癌は，唾液腺型肺癌に分類される稀な腫瘍である．<b>症例．</b>26歳男性．血痰を契機に当院に入院となり，右上幹腫瘍および右上葉無気肺を指摘された．気管支鏡検査で右上幹入口部に表面平滑な結節を認め，自家蛍光気管支内視鏡画像ではマゼンタ色を呈していた．生検で確定診断に至らなかったが，悪性疾患の可能性が高いと判断した．当院呼吸器外科にて胸腔鏡補助下右上葉スリーブ切除を施行し，低悪性度気管支原発粘表皮癌の診断に至った．<b>結論．</b>若年男性に発症し，右上葉スリーブ切除を行った気管支原発粘表皮癌の症例を経験した．完全切除された気管支原発低悪性度粘表皮癌は予後良好とされているが，再発の有無について注意深い経過観察が必要である．</p> DOI： 10.18907/jjsre.41.2_193 CiNii Research
• 隈元 朋洋, 冨岡 勇也, 松山 洋美, 鵜木 泰自, 谷川 健悟, 堂嶽 洋一, 三山 英夫, 籾 博晃, 佐藤 雅美, 井上 博雅2019 · 出版者・発行元： (NPO)日本呼吸器内視鏡学会

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