Kagoshima University · Perinatal Maternal and Child Care Center

Research keywordsgynecologic oncology・endometrial cancer・cervical cancer・sentinel lymph node navigation・robotic surgery・endometrial cytology・immunotherapy biomarkers・HPMA nanomedicine

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• Onigahara Motohisa, Yanazume Shintaro, Torisu Hiromichi, Kobayashi Hiroaki2024 · 記述言語： 英語 出版者・発行元： John Wiley & Sons Australia, Ltd
• 中薗 麻衣, 水野 美香, 岩尾 葵, 簗詰 伸太郎, 戸上 真一, 小林 裕明2024 · 記述言語： 日本語 出版者・発行元： 鹿児島産科婦人科学会
• 中薗 麻衣, 水野 美香, 岩尾 葵, 簗詰 伸太郎, 戸上 真一, 小林 裕明 . 当院における高齢者のロボット手術の成績とリスク評価 . 鹿児島産科婦人科学会雑誌32 28 - 35 2024年3月 詳細を見る 記述言語： 日本語 出版2024 · 記述言語： 日本語 出版者・発行元： 鹿児島産科婦人科学会 当院でロボット手術を行った30例を対象に、これらを70～74歳の准高齢者群(A群)17例と、75歳以上の高齢者群(B群)13例に分け、治療成績や周術期合併症を比較検討した。その結果、両群間で治療成績、周術期合併症に有意差はみられなかった。周術期リスク評価システムを用いた算定結果を含めると、年齢にかかわらずロボット手術は比較的安全に行えることが示唆された。
• Yanazume S., Kirita Y., Kobayashi Y., Kitazono I., Akahane T., Mizuno M., Togami S., Tanimoto A., Kobayashi H. . Can Endometrial Cytology Identify Patients Who Would Benefit from Immunotherapy2024 · 記述言語： 日本語 出版者・発行元： Acta Cytologica mutation (POLEmut) subtype, MMR-deficient (MMR-d) subtype as classified by The Cancer Genome Atlas (TCGA), and a high tumor mutation burden (TMB-high) potentially benefit from immunotherapy. However, characteristics of the cytological morphology within these populations remain unknown. Methods: DNA extracted from formalin-fixed paraffinembedded tissues was subjected to next-generation sequencing analysis. Genomic mutations related to gynecological cancers, TMB, and microsatellite instability were analyzed and were placed in four TCGA classification types. The following morphological cytological investigations were conducted on endometrial cancer using a liquid-based preparation method, prior to the commencement of initial treatment: (i) cytological backgrounds; (ii) differences between each count of neutrophils and lymphocytes as described below. Results: Insignificant differences in the cytological background patterns of TCGA groups and TMB status were found. Although there was no significant difference in neutrophil count (p = 0.955) in the TCGA groups, POLEmut and MMR-d had significantly higher lymphocyte counts than no specific molecular profile (NSMP) (p = 0.019 and 0.037, respectively); furthermore, p53mut also tended to be significant (p = 0.064). Lymphocyte counts in TMB-high were also significantly greater than TMB-low (p = 0.002). POLEmut showed a positive correlation between TMB levels and lymphocyte counts. For predicting patients with POLEmut plus MMRd, lymphocyte counts demonstrated a superior diagnostic accuracy of area under the curve (AUC) (0.70, 95% CI: 0.57-0.84), with a cutoff value of 26 high-power field. Conclusion: Lymphocyte count using liquid-based cytology for patients with endometrial cancer may predict POLEmut plus MMR-d of TCGA groups and TMB-high in those who can benefit from immunotherapy. 2024 S. Karger AG, Basel. DOI： 10.1159/000538288 Scopus PubMed

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