Kagoshima University · Graduate School of Medical and Dental Sciences

Research keywordsacute stress responses・amygdala gene regulation・fear learning・Arc expression・schizophrenia genetics・synaptic function・behavioral neuroscience

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• 城山 優治, 大西 哲生, 有馬 史子, 門田 満隆, 尾藤 晴彦, 吉川 武男, 真鍋 俊也, 奥野 浩行2021 · 記述言語： 英語 出版者・発行元： (公社)日本生化学会
• Ohnishi T, Kiyama Y, Arima-Yoshida F, Kadota M, Ichikawa T, Yamada K, Watanabe A, Ohba H, Tanaka K, Nakaya A, Horiuchi Y, Iwayama Y, Toyoshima M, Ogawa I, Shimamoto-Mitsuyama C, Maekawa M, Balan S, Ar2020 · 担当区分： 筆頭著者 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： EMBO Molecular Medicine Genomic defects with large effect size can help elucidate unknown pathologic architecture of mental disorders. We previously reported on a patient with schizophrenia and a balanced translocation between chromosomes 4 and 13 and found that the breakpoint within chromosome 4 is located near the LDB2 gene. We show here that Ldb2 knockout (KO) mice displayed multiple deficits relevant to mental disorders. In particular, Ldb2 KO mice exhibited deficits in the fear-conditioning paradigm. Analysis of the amygdala suggested that dysregulation of synaptic activities controlled by the immediate early gene Arc is involved in the phenotypes. We show that LDB2 forms protein complexes with known transcription factors. Consistently, ChIP-seq analyses indicated that LDB2 binds to > 10,000 genomic sites in human neurospheres. We found that many of those sites, including the promoter region of ARC, are occupied by EGR transcription factors. Our previous study showed an association of the EGR family genes with schizophrenia. Collectively, the findings suggest that dysregulation in the gene expression controlled by the LDB2-EGR axis underlies a pathogenesis of subset of mental disorders. DOI： 10.15252/emmm.202012574 Scopus PubMed
• Naruse Y, Miyajima K, Sugiura R, Muto M, Ogano M, Kurebayashi N, Shiozawa T, Kiyama Y, Nagata E, Odagiri K, Maekawa Y, Mt. FUJI trial investigators . Comparison of delivery catheter-bas2020 · 記述言語： 英語 DOI： 10.1136/bmjopen-2020-046782 PubMed
• Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M.2016 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌）

• 生化学2019 · 2019年4月 - 現在
• ストレス下で心の平穏を保つための脳神経回路2019 · 担当区分： 研究代表者 資金種別： 競争的資金
• 活動神経のプロファイリングを通じた扁桃体機能解析2015 · 担当区分： 研究代表者 資金種別： 競争的資金
• ドミナント・ネガティブ型Ｃｒｅを応用した扁桃体特異的遺伝子ＫＯマウスの作成と解析2011 · 研究課題/領域番号： 23700488 2011年4月 - 2014年3月

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