Ryugaku Jinja · Professor Archive
Public Professor Archive
西谷 登美子西谷 登美子
Kagoshima University · Graduate School of Medical and Dental Sciences
- Publications
- 4
- Keywords
- 6
留学
神社Kagoshima University · Graduate School of Medical and Dental Sciences
Research keywordspulp capping materials・dentin bond strength・calcium ion release・regenerative dentistry・dental restorative materials・nanomaterials in dentistry
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- 西谷 登美子, 達山 祥子, 高 裕子, 勝俣 愛一郎, 星加 知宏, 西谷 佳浩2021 · 記述言語: 日本語 出版者・発行元: 日本再生歯科医学会
- Sato T. . Distribution of alpha-synuclein in the rat cranial sensory ganglia, and oro-cervical regions . Annals of Anatomy238 151776 2021年11月 詳細を見る 記述2021 · 記述言語: 日本語 出版者・発行元: Annals of Anatomy Background: Alpha-synuclein (Syn), an unfolded soluble cytosolic protein, is known as a disease-associated protein in the brain. However, little is known about distribution of this protein in the peripheral nervous system. In this study, expression of Syn was investigated in the sensory ganglia of the cranial nerves V, IX and X. Methods: To analyze distribution of Syn and its co-expression with calcitonin gene-related peptide (CGRP) or the transient receptor potential cation channel subfamily V member 1 (TRPV1), immunohistochemical techniques were used in the rat cranial sensory ganglia and their peripheral tissues. Results: Syn-immunoreactive (-ir) neurons were abundant in the sensory ganglia of the petrosal (56.7%), jugular (28.3%) and nodose ganglia (82.5%). These neurons had small to medium-sized cell bodies (petrosal, mean ± S.D. = 667.4 ± 310.8 μ m2; jugular, 625.1 ± 318.4 μ m2; nodose, 708.3 ± 248.3 μ m2), and were distributed throughout the ganglia. However, the trigeminal ganglion was mostly free of Syn-ir neurons. By double and triple immunofluorescence staining, Syn-ir neurons co-expressed CGRP and TRPV1 in the petrosal and jugular ganglia. Syn-immunoreactivity was expressed by nerve fibers in the epithelium and taste bud of oral and cervical viscerae. These nerve fibers were abundant in the naso-pharynx, epiglottis and laryngeal vestibule. Some taste bud cells were also immunoreactive for Syn. In addition, Syn-ir nerve fibers were detected in the vicinity of macrophages, dendritic cells and Langerhans cells. Conclusions: Syn was abundant in the visceral sensory neurons but not in somatic sensory neurons. This protein may play a role in nociceptive and chemosensory transduction in the glossopharyngeal and vagal sensory ganglia. It is possible that Syn has a function about the immune mechanism of the upper air way. DOI: 10.1016/j.aanat.2021.151776 Scopus PubMed
- 西谷 登美子, 達山 祥子, 高 裕子, 勝俣 愛一郎, 星加 知宏, 西谷 佳浩 . 試作覆髄剤の象牙質接着強さとカルシウムイオン徐放について . 日本再生歯科医学会誌19 ( 1 ) 1 - 9 2021年3月 詳細2021 · 記述言語: 日本語 出版者・発行元: 日本再生歯科医学会 接着性を有する覆髄剤の開発を目的として、Mineral trioxide aggregate(MTA)と親水性モノマーで重合硬化させる覆髄剤を試作した。MTAとモノマーの比率が異なる2種の試作覆髄剤および市販の覆髄剤を実験に供した。材料の基本性能となる象牙質と試作覆髄剤のせん断接着強さ、象牙質辺縁封鎖性および試作覆髄剤からのカルシウムイオン徐放について検討を行った。その結果、本研究で試作した覆髄剤は、市販の覆髄剤よりも良好な象牙質辺縁封鎖性を示し、接着強さも高かった。またモノマーとMTAの配合比が異なる試作覆髄剤間での比較では、相対的にモノマーの比率が高い方が接着強さは高く、MTAの比率が高い覆髄剤では象牙質辺縁封鎖性に優れ、材料からのカルシウムイオン徐放量が多くなる可能性が示唆された。MTAとモノマーの配合比率が覆髄剤の基本性能に影響する可能性があることから、今後さらに、象牙質辺縁封鎖性に優れた高い接着強さが得られる配合比率について検討を行う予定である。(著者抄録)
- 星加 知宏, 勝俣 愛一郎, 丁 群展, 西谷 登美子, 髙 裕子, 勝俣 環, 根本 章, 伊藤 誠之, 岩田 知幸, 林 宏昌, 永山 雅大, 永山 祥子, 西谷 佳浩 . 新規覆髄剤の細胞増殖ならびに象牙質剪断接着強さへの影響について . 日本歯科保存学雑誌.62(4) 2019年8月 詳細を見る 記述言2019 · 記述言語: 日本語 掲載種別: 研究論文(学術雑誌)
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