Kagoshima University · Institute of Medical and Dental Sciences, University Hospital

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• Uchiyama Nami, Yuasa Toshinori, Miyata Masaaki, Horizoe Yoshihisa, Chaen Hideto, Kubota Kayoko, Takasaki Kunitsugu, Mizukami Naoko, Kisanuki Akira, Ohishi Mitsuru2019 · 出版者・発行元： (一社)日本循環器学会
• Yuasa T. . Fabry disease . Journal of Echocardiography15 ( 4 ) 151 - 157 2017年12月 詳細を見る 出版者・発行元： Journal of Echocardiography2017 · 出版者・発行元： Journal of Echocardiography DOI： 10.1007/s12574-017-0340-x Scopus PubMed
• Uchiyama Nami, Yuasa Toshinori, Miyata Masaaki, Horizoe Yoshihisa, Chaen Hideto, Kubota Kayoko, Takasaki Kunitsugu, Mizukami Naoko, Kisanuki Akira, Ohishi Mitsuru . Correlation of Right Ventri出版者・発行元： 一般社団法人 日本循環器学会 <p><b><i>Background: </i></b>This study was designed to investigate the relationship between right ventricular wall stress (RVWS) and plasma B-type natriuretic peptide (BNP) levels in patients with pulmonary hypertension (PH). </p><p><b><i>Methods and Results: </i></b>The 57 consecutive PH patients and 8 control subjects were enrolled. Right heart catheterization (RHC), echocardiography, and BNP measurements were performed, and RVWS and left ventricular wall stress (LVWS) were calculated with the formula based on Laplace's law. Systolic RVWS and end-diastolic RVWS were higher in PH patients compared with controls (systolic RVWS: 77±41 vs. 17±5 kdynes/cm²(P<0.0001), end-diastolic RVWS: 15±12 vs. 8±2 kdynes/cm²(P<0.0005)). Univariate analyses showed that logBNP at baseline correlated with systolic RVWS (r=0.58, P<0.0001) and end-diastolic RVWS (r=0.61, P<0.0001). We performed multivariate regression analysis and determined that end-diastolic RVWS was an independent determinant of logBNP in patients with PH. In addition, change in plasma BNP levels after treatment correlated with change in systolic RVWS (r=0.70, P<0.0001) and change in end-diastolic RVWS (r=0.68, P<0.0001). </p><p><b><i>Conclusions: </i></b>Both systolic and end-diastolic RVWS were elevated in patients with PH, and correlated with the symptoms of PH. End-diastolic RVWS was an independent determinant of plasma BNP levels in PH patients. </p> DOI： 10.1253/circj.CJ-18-1155 Scopus PubMed CiNii Research
• Uchiyama Nami, Yuasa Toshinori, Miyata Masaaki, Horizoe Yoshihisa, Chaen Hideto, Kubota Kayoko, Takasaki Kunitsugu, Mizukami Naoko, Kisanuki Akira, Ohishi Mitsuru . 肺高血圧症患者における右室壁応力と血漿脳出版者・発行元： (一社)日本循環器学会 肺高血圧症(PH)患者における右室壁応力(RVWS)の臨床的意義を調べ、RVWSと脳性ナトリウム利尿ペプチド(BNP)との相関を明らかにした。右心カテーテル法(RHC)で肺高血圧症(PH)と診断された患者57例(男性13例、女性44例、平均60±15歳)と対照8名(男性4名、女性4名、平均65±8歳)から血液検体を採取し、血漿BNPを測定した。心エコーを行い、RHCを実施して血行動態を調査して、RVWSを計算した。収縮期RVWSはPH群が77±41kdynes/cm2、対照群が17±5kdynes/cm2、拡張終期RVWSは15±12kdynes/cm2と8±2kdynes/cm2で、PH群の方が高かった。単変量解析ではベースラインでのlogBNPは収縮期RVWS、拡張終期RVWSと関連した。多変量回帰分析では拡張終期RVWSがPH群のlogBNPの独立決定因子であった。治療後の血漿BNPにおける変化は収縮期RVWSと拡張終期RVWSにおける変化と関連した。

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