Kagoshima University · Graduate School of Science and Engineering · 准教授

Research keywordsオタマボヤ・ハウス・ライブイメージング・左右非対称形成・発生生物学・遺伝子スクリーニング・脊索動物・3D形成・DNA interference・オタマジャクシ型の発生

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• Wang K, Suyama R, Mizutani N, Matsuo M, Peng Y, Seki M, Suzuki Y, Luscombe NM, Dantec C, Lemaire P, Toyoda A, Nishida H, Onuma TA . Transcriptomes of a fast-developing chordate uncover2026 · 担当区分： 最終著者, 責任著者 記述言語： 英語 掲載種別： 研究論文（学術雑誌） DOI： 10.1242/dev.202666
• Sasakura Y, Sunanaga T, Onuma TA, Satake H . Germ cell formation and reproduction in tunicates. . Developmental Biology527 226 - 2492025 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） DOI： https://doi.org/10.1016/j.ydbio.2025.08.013
• Nicholas Treen, Shohei Konishi, Hiroki Nishida, Takeshi A Onuma, Yasunori Sasakura . Zic-r.b controls cell numbers in Ciona embryos by activating CDKN1B. . Developmental2023 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） The control of cell numbers and the establishment of cell types are two processes that are essential in early embryonic development. We have a reasonable understanding of how these processes occur individually, but we have considerably less sophisticated understanding of how these processes are linked. Tunicates have fixed cell lineages with predictable cell cycles, making them well suited to investigate these processes. In the ascidian Ciona, we show that the transcription factor Zic-r.b, known to be involved in establishing several cell types in early development also activates the expression of the cell cycle inhibitor CDKN1B. Zic-r.b is a major missing component of the cell division clock establishing specific cell numbers. We also show that a larvacean homolog of Zic-r.b is expressed one cell cycle earlier than its Ciona counterpart. The early expression in larvaceans may explain why they have half as many notochord cells as ascidians and may illustrate a general mechanism to evolve changes in morphology. DOI： 10.1016/j.ydbio.2023.03.005 PubMed researchmap
• Onuma TA, Nakanishi R, Sasakura Y, Ogasawara M . Nkx2-1 and FoxE regionalize glandular (mucus-producing) and thyroid-equivalent traits in the endostyle of the chordate Oikopleura dioica2021 · 担当区分： 筆頭著者, 責任著者 記述言語： 英語 掲載種別： 研究論文（学術雑誌） DOI： 10.1016/j.ydbio.2021.05.021 PubMed researchmap

• オタマボヤの未受精卵と初期胚の凍結保存技術の開発2025 · 資金種別： 競争的資金 配分額： 500000円 （ 直接経費： 500000円 ）
• 生物学の最先端2025 · 2025年 - 現在
• 表皮細胞による動物性繊維をもちいたハウス建築2024 · 担当区分： 研究代表者 配分額： 31000000円
• 分子生物学I2024 · 2024年 - 現在

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