Kagoshima University · Graduate School of Science and Engineering · 教授

Research keywords立体選択的有機合成・Stereo selective organic Synthesis・天然物合成・不斉合成・金ナノ粒子・有機化学

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• Koze Hinako, Sudoh Masayuki, Onitsuka Satoaki, Okamura Hiroaki, Ishikawa Takeshi, Tani Fumito, Miyata-Yabuki Yukako, Shirouzu Mikako, Baba Masanori, Okamoto Mika, Hamada Toshiyuki2025 · 記述言語： 英語 出版者・発行元： シュプリンガー・ジャパン(株)
• Nakamura R., Matsuyama K., Arima N., Tani F., Onitsuka S., Okamura H., Iwagawa T., Sudoh M., Hamada T. . Isolation, characterization, and biological activities of halogenated sesquiterpenes an2025 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Tetrahedron The sea hare, scientifically known as Aplysia argus, is the focus of considerable research interest owing to its unique halogenated metabolites that may have vast potential in the fields of medicine and pharmaceuticals. This paper reports the isolation of a new laurane-type sesquiterpene, 10-bromoisolaurinsiol (1), and a new halogenated C<inf>15</inf> acetogenin (2), along with several known halogenated secondary metabolites from the sea hare Aplysia argus. Their structures and relative stereochemistries were established through comprehensive 1D and 2D NMR analyses. Fourteen compounds, some of which were novel, were evaluated for their cytotoxic effects against S1T cells (a cancer cell line derived from adult T-cell leukemia patients) and their potential as SARS-CoV-2 main protease inhibitors. DOI： 10.1016/j.tet.2025.134588 Scopus
• Tetsuo Iwagawa, Miho Miyazaki, Yukiko Yokogawa, Hiroaki Okamura, Munehiro Nakatani, Matsumi Doe, Yoshiki Morimoto, and Kaoru Takemura2023 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌）
• Matsuyama K., Inoue T., Muroga T., Arima N., Doe M., Tani F., Ookawa Y., Okamoto Y., Onitsuka S., Okamura H., Iwagawa T., Hamada T. . New halogenated C15 acetogenins from Okinawan s2022 · 記述言語： 日本語 出版者・発行元： Tetrahedron Two new C15 acetogenins 1 and 2, along with four known sesquiterpenes isolaurenisol (3), laurokamurene D (4), itomanol (5), and acetylelatol (6), were isolated from sea hare Aplysia dactylomela. The structures, including the relative stereochemistries, of 1 and 2 were determined based on spectroscopic evidence. Finally, the in vitro cytotoxicities of the six compounds against S1T cells, an adult T-cell leukemia cell line, were evaluated. DOI： 10.1016/j.tet.2022.132889 Scopus

• 抗菌・防かび・抗ウイルス性を付与できる画期的塗布剤の開発～酸化亜鉛ナノ粒子上への抗菌剤の集積化による機能強化と物性の改良2019 · 塗るだけで抗菌・防かび・抗ウイルス性を付与できる塗布剤の開発を行う。抗菌・防かび・抗ウイルス性のポリヘキサメチレンビグアニド（PHMB）－酸化亜鉛ナノ粒子複合体を塗料等に添加することで、使途の広い機能性塗布剤とする。
• 糖尿病治療薬として期待されるアミノシクリトール類の新しい不斉合成法の研究
• 還元性安定化剤ミセルを用いた金ナノ材料の形状制御合成と機能性分子の配列制御の研究
• asymmetric synthesis of natural products

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