Kagoshima University · Graduate School of Medical and Dental Sciences · 准教授

Research keywords味覚・味蕾・細胞分化・味覚受容・神経情報伝達・ターンオーバー・オルガノイド

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• Eriko Koyanagi-Matsumura, Hirohito Miura, Mitsuru Saito, Shuitsu Harada2020 · 担当区分： 責任著者 記述言語： 英語 掲載種別： 研究論文（学術雑誌）
• Tomonari H, Miura H, Nakayama A, Matsumura E, Ooki M, Ninomiya Y, Harada S . Gα-gustducin is extensively coexpressed with sweet and bitter taste receptors in both the soft palate and fungiform2016 · DOI： 10.1093/chemse/bjr098 PubMed
• 原田 秀逸, 三浦 裕仁 . 老化に伴うラットの味覚嗜好性の変化 . 鹿児島大学歯学部紀要35 ( 35 ) 11 - 19 2015年3月 詳細を見る 記述言語： 日本語 出版者・発行元： 鹿児島大学歯学部 The effect of aging2015 · 記述言語： 日本語 出版者・発行元： 鹿児島大学歯学部 The effect of aging on taste were compared between the preference and neural responses from the greater superficial petrosal nerve (GSP) innervating the soft palate and the chorda tympani nerve (CT) innervating the fungiform papillae in the young (5-12 weeks) and aged (19-22 months) Sprague Dawley rat. A two-bottle preference test revealed that younger rats significantly preferred 0.001 M 5'-inosine monophosphate (IMP), 0.01 M mono sodium glutamate (MSG), and binary mixtures of 0.001 M IMP + 0.01 M MSG than deionized water. However, aged rats showed no significant preference to these umami solutions. Among the other four basic taste stimuli, there was no significant difference in preference between young and aged rats. Regardless of the age of the rat, neural responses from the GSP and CT produced robust integrated responses to all three umami solutions the same as used in the two-bottle test. These results indicate that the lack of preference to umami in aged rats is occurred in the central nervous system, suggesting that the loss of preference to umami taste in aged rats may be caused by homeostatic changes in the brain. CiNii Research 機関リポジトリURL その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J00245&link_issn=&doc_id=20150522030002&doc_link_id=http%3A%2F%2Fhdl.handle.net%2F10232%2F26722&url=http%3A%2F%2Fhdl.handle.net%2F10232%2F26722&type=%8E%AD%8E%99%93%87%91%E5%8Aw%81F%8E%AD%8E%99%93%87%91%E5%8Aw%83%8A%83%7C%83W%83g%83%8A&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80042_3.gif
• Hirohito Miura, Yuko Kusakabe, Kento Hashido, Akihiro Hino, Makoto Ooki, Shuitsu Harada . The glossopharyngeal nerve controls epithelial expression of Sprr2a and Krt13 around taste buds in the2014 · 出版者・発行元： ELSEVIER IRELAND LTD Tastants reach the tip of taste bud cells through taste pores which are openings in the epithelium. We found Sprr2a is selectively expressed in the upper layer of the epithelium surrounding taste buds in the circumvallate papilla (CV) where the epithelium is organized into taste pores. Sprr2a is a member of a small proline-rich protein family, which is suggested to be involved in the restitution/migration phase of epithelial wound healing. The expression of Sprr2a was restricted to the upper layer and largely segregated with Ptch1 expression that is restricted to the basal side of the epithelium around the taste buds. Denervation resulted in the gradual loss of Sprr2a-expressing cells over 10 days similarly to that of taste bud cells which is in contrast to the rapid loss of Ptch1 expression. We also found that denervation caused an increase of Keratin (Krt)13 expression around taste buds that corresponded with the disappearance of Sprr2a and Ptch1 expression. Taste buds were surrounded by Krt13-negative cells in the CV in control mice. However, at 6 days post-denervation, taste buds were tightly surrounded by Krt13-positive cells. During taste bud development, taste bud cells emerged together with Krt13-negtive cells, and Sprr2a expression was increased along with the progress of taste bud development. These results demonstrate that regional gene expression surrounding taste buds is associated with taste bud formation and controlled by the innervating taste nerve. (C) 2014 Elsevier Ireland Ltd. All rights reserved. DOI： 10.1016/j.neulet.2014.08.012 Web of Science

• 味蕾基底細胞の再定義：「細胞型分化の解明」と「味蕾オルガノイド評価系の確立」2020 · 配分額： 4290000円 （ 直接経費： 3300000円 、 間接経費： 990000円 ）
• 鹿児島県 高等学校教育研究会 家庭部会 研修会 講師2018 · 2018年08月
• 味を感じるしくみ2018 · 熊本県高等学校教育研究会 平成30年度 熊本県 高等学校教育研究会 家庭科研修 2018年11月12日
• 熊本県 高等学校教育研究会 家庭部会 研修会 講師2018 · 2018年11月

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