Kagoshima University · Graduate School of Medical and Dental Sciences · 講師

Research keywords医学・歯学

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• 坂田 大治, 野元 裕輔, 山本 雅裕, 中嶋 千紗, 椛島 健治, 吉田 裕樹, 金蔵 拓郎, 原 博満 . IL-27による痒み感覚の抑制 . 日本薬理学会年会要旨集97 ( 0 ) 3-B-O09-3 2023年 詳細を見る 記述言語： 日本語 出版者・発行元： 公益社団法2023 · 記述言語： 日本語 出版者・発行元： 公益社団法人 日本薬理学会 <p>Physiological itch is crucial for host defense because scratching behavior leads to removing potentially harmful organism from the skin. However, itch in chronic disease such as atopic dermatitis induces unpleasant effects. Recent studies have paid attention to type2 cytokines including IL-4, IL-13 and IL-31 as allergic dermatitis-associated itch mediators. Indeed, receptors of these cytokines are expressed on dorsal root ganglion neurons and the cytokines can activate and/or sensitize the neurons directly. However, immune regulation of itch sensation has not yet been fully understood.</p><p>IL-27 is an immunoregulatory cytokine which belongs to IL-12 cytokine family. IL-27 is mainly produced by antigen-presenting cells and transmits the signals via a heterodimeric receptor composed of IL-27 receptor a chain (WSX-1) and gp130. Although IL-27 suppresses Th2 and ILC2 responses, the role of IL-27 in neural system remains to be elucidated.</p><p>Here, we found that mice deficient in WSX-1 showed enhanced scratching behavior against several pruritogens. Conversely, administration of recombinant IL-27 suppressed pruritogen-induced scratching behavior in WT mice. This suppressive effect of IL-27 in itch sensation is abolished in Nav1.8-Cre WSX-1^flox/flox mice which lack sensory neuron specific WSX-1 expression. In addition, treatment with JAK kinase inhibitor abrogates the effect of IL-27 in scratching behavior. These results imply that IL-27 acts on sensory neuron and suppresses neuronal activity by JAK kinase-dependent manner, leading to regulatory function in itch sensation.</p> DOI： 10.1254/jpssuppl.97.0_3-b-o09-3 CiNii Research
• Tatsuguchi Takaaki, Uruno Takehito, Sugiura Yuki, Sakata Daiji, Izumi Yoshihiro, Sakurai Tetsuya, Hattori Yuko, Oki Eiji, Kubota Naoto, Nishimoto Koshiro, Oyama Masafumi, Kunimura Kazufumi, Ohki Takuto, Bamba Takeshi, Tahara Hideaki, Sakamoto Michiie, Nakamura Masafumi, Suematsu Makoto, Fukui Yoshinori2022 · 記述言語： 英語 出版者・発行元： Oxford University Press
• Aihara Ryosuke, Kunimura Kazufumi, Watanabe Mayuki, Uruno Takehito, Yamane Nana, Sakurai Tetsuya, Sakata Daiji, Nishimura Fusanori, Fukui Yoshinori2021 · 記述言語： 英語 出版者・発行元： Oxford University Press
• Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion.

• 難治性肺疾患におけるmDiaの役割の解析
• 腫瘍免疫におけるプロスタノイド受容体の役割の解析
• TP及びIPの免疫系における役割の解析
• 神経免疫炎症における異物除去蛋白質AIMの役割の解析

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