Kagoshima University · Graduate School of Medical and Dental Sciences · 准教授

Research keywords肥満症治療薬・miR-494・糖尿病治療薬・incretin-based diabetes therapy・SGLT2阻害薬関連DKA・アナグリプチン/メトホルミン配合錠・GLP-1胃排出遅延・二重標識水法・ヒト肥満エネルギー代謝

This is a public-data preview. Personalized fit, contact angles, and saved workflows require sign-in.

• 小川 渉, 田村 好史, 石井 好二郎, 石垣 泰, 永井 成美, 廣田 勇士, 森野 勝太郎, 井ノ口 美香子, 鈴木 公啓, 田中 栄, 寺内 公一, 能瀬 さやか, 日本肥満学会, 女性の低体重, 低栄養症候群ワーキンググループ . 【女性の低体重/低栄養症候群(FUS)ステートメント】閉経前までの成人女性における低体重や低栄養による健康課題 新たな症候群の確立について2025 · 記述言語： 日本語 出版者・発行元： (一社)日本肥満学会
• Seiichiro Ohgaku, Shogo Ida, Natsuko Ohashi, Katsutaro Morino, Atsushi Ishikado, Tsuyoshi Yanagimachi, Koichiro Murata, Daisuke Sato, Satoshi Ugi, Ali Nasiri, Gerald I Shulman, Hiroshi Maegawa, Shinji2024 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） INTRODUCTION: Endothelial cells have a crucial function in transporting and exchanging various nutrients. O-GlcNAcylation, mediated by O-GlcNAc transferase (OGT), involves the addition of N-acetylglucosamine to proteins and serves as an intracellular nutrient sensing mechanism. However, the role of O-GlcNAcylation in endothelial cells remains poorly understood. OBJECTIVE: This study investigated the role of O-GlcNAcylation in endothelial cells. METHODS: Endothelial-cell-specific Ogt -knockout mice (Ogt-ECKO) were generated by crossing Ogt-floxed mice (Ogt-flox) with VE-Cadherin Cre ERT2 mice. Ogt-ECKO mice and Ogt-flox control mice were subjected to a normal or high-fat diet, and their body weight, glucose metabolism, and lipid metabolism were examined. RESULTS: Ogt-ECKO mice exhibited reduced body weight compared with Ogt-flox control mice under a high-fat diet. Lipid absorption was significantly impaired in Ogt-ECKO mice. Changes in the intercellular junctions of small intestinal lacteal endothelial cells from a button-like to a zipper-like configuration were observed. Furthermore, Ogt-ECKO mice showed decreased expression of VEGFR3. The administration of a nitric oxide donor restored lipid absorption and reversed the morphological alterations in Ogt-ECKO mice. CONCLUSIONS: These findings demonstrate the critical role of O-GlcNAcylation in endothelial cells in lipid absorption in the intestine through the modulation of lacteal junction morphology. These results provide novel insight into the metabolic regulatory mechanisms under physiological conditions and have implications for the development of new therapeutic strategies for obesity. DOI： 10.1016/j.heliyon.2024.e34490 PubMed
• Asraa Faris Aldoghachi, Daijiro Yanagisawa, Aslina Pahrudin Arrozi, Zulzikry Hafiz Abu Bakar, Hiroyasu Taguchi, Shinsuke Ishigaki, Katsutaro Morino, Ikuo Tooyama . Fluorinated curcumin2023 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） Thioredoxin interacting protein (TXNIP) has emerged as a significant regulator of β-cell mass and loss, rendering it an attractive target for treating diabetes. We previously showed that Shiga-Y6, a fluorinated curcumin derivative, inhibited TXNIP mRNA and protein expression in vitro, raising the question of whether the same effect could be translated in vivo. Herein, we examined the effect of Shiga-Y6 on TNXIP levels and explored its therapeutic potential in a mouse model of diabetes, Akita mice. We intraperitoneally injected Shiga-Y6 (SY6; 30 mg/kg of body weight) or vehicle into 8-week-old Akita mice for 28 consecutive days. On day 29, the mice were euthanized, following which the serum levels of glucose, insulin, and glucagon were measured using ELISA, the expression of TXNIP in pancreatic tissue lysates was determined using western blotting, and the level of β-cell apoptosis was assessed using the TUNEL assay. TXNIP levels in the pancreatic tissue of Akita mice were significantly elevated compared with wild-type (WT) mice. Shiga-Y6 administration for 28 days significantly lowered those levels compared with Akita mice that received vehicle to a level comparable to WT mice. In immunohistochemical analysis, both α- to β-cell ratio and the number of apoptotic β-cells were significantly reduced in SY6-treated Akita mice, compared with vehicle-treated Akita mice. Findings from the present study suggest a potential of Shiga-Y6 as an antidiabetic agent through lowering TXNIP protein levels and ameliorating pancreatic β-cells apoptosis. DOI： 10.1016/j.bbrc.2023.149392 PubMed
• 佐藤 麻子, 川浪 大治, 藤川 るみ, 菅沼 由美, 古橋 眞人, 森野 勝太郎, 山本 恭子, 和田 幹子, 井町 仁美, 岡田 由紀子, 川崎 麻紀, 近藤 敬一, 笹岡 利安, 高橋 倫子, 富樫 優, 中島 華子, 橋本 尚子, 藤本 啓, 別所 瞭一, 的場 ゆか, 宮 愛香, 安孫子 亜津子, 糖尿病医療者・研究者のダイバーシティをpromoteする委員会 . メディ2023 · 記述言語： 日本語 出版者・発行元： (一社)日本糖尿病学会 添付ファイル： 雑誌糖尿病_2023ダイバーシティ.pdf

• 日本人の食事摂取基準（2025年版）策定検討会ワーキンググループ2025 · 厚生労働省 2023年09月 - 2024年03月31日
• メタボロミクスを用いた高齢一般女性の認知症およびフレイル発症要因の疫学的解明2025 · 担当区分： 研究代表者 資金種別： 競争的資金 配分額： 18850000円 （ 直接経費： 14500000円 、 間接経費： 4350000円 ）
• 健常者における加齢に伴う血糖変動が認知機能と脳容積に及ぼす影響2024 · 担当区分： 研究代表者 資金種別： 競争的資金 配分額： 4550000円 （ 直接経費： 3500000円 、 間接経費： 1050000円 ）
• 鹿児島県糖尿病協会 副会長2024 · 2024年06月 - 現在

• Official profile