Kagoshima University · Graduate School of Medical and Dental Sciences · 教授

Research keywords神経生理学・機能系基礎歯科学・Neurophysiology・Functional Basic Dentistry・三叉神経系・咀嚼機能・GABA受容体・咬合力・運動ニューロン

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• Toyoda H, Fujinami Y, Saito M, Maeda Y, Kang Y . Increased vertical dimension of occlusion for varying periods differentially impairs learning and memory in guinea pigs . Behavioural B2023 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） DOI： 10.1016/j.bbr.2023.114547
• 歯科生理学実習 第２版（岩田 幸一, 井上 富雄, 舩橋 誠, 加藤 隆史, 重村 憲徳, 篠田 雅路, 小野 堅太郎 編）2022 · 医歯薬出版 2022年3月 （ ISBN: 978-4-263-45869-3 ）
• Hiroki Toyoda, Jonghwa Won, Wheedong Kim, Hayun Kim, Oscar Davy, Mitsuru Saito, Doyun Kim, Takuma Tanaka, Youngnam Kang, Seog Bae Oh . The Nature of Noradrenergic Volume Transmission From Locu2022 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Frontiers Research Foundation Noradrenergic neurons in the locus coeruleus (LC) release noradrenaline (NA) that acts via volume transmission to activate extrasynaptic G-protein coupled receptors (GPCRs) in target cells throughout the brain. As the closest projection, the dorsal LC laterally adjoins the mesencephalic trigeminal nucleus (MTN), in which proprioceptive primary sensory neurons innervating muscle spindles of jaw-closing muscles are exceptionally located. MTN neurons express α2-adrenergic receptors (α2-ARs) and display hyperpolarization-activated cyclic nucleotide-gated (HCN) currents (Ihs), which is downregulated by α2-AR activation. To quantify the activity-dependent outcome of volume transmission of NA from LC to MTN, we investigated how direct LC activation inhibits Ih in MTN neurons by performing dual whole-cell recordings from LC and MTN neurons. Repetition of 20 Hz spike-train evoked with 1-s current-pulse in LC neurons every 30 s resulted in a gradual decrease in Ih evoked every 30 s, revealing a Hill-type relationship between the number of spike-trains in LC neurons and the degree of Ih inhibition in MTN neurons. On the other hand, when microstimulation was applied in LC every 30 s, an LC neuron repeatedly displayed a transient higher-frequency firing followed by a tonic firing at 5-10 Hz for 30 s. This subsequently caused a similar Hill-type inhibition of Ih in the simultaneously recorded MTN neuron, but with a smaller Hill coefficient, suggesting a lower signal transduction efficacy. In contrast, 20 Hz activity induced by a 1-s pulse applied every 5-10 s caused only a transient facilitation of Ih inhibition followed by a forced termination of Ih inhibition. Thus, the three modes of LC activities modulated the volume transmission to activate alpha2-adrenergic GPCR to differentially inhibit Ih in MTN neurons. DOI： 10.3389/fncel.2022.841239
• Tanaka Y, Sato H, Toyoda H, Saito M, Maeda Y, Kang Y . The mechanism for regulating the isometric contraction of masseter muscles is involved in determining the vertical dimension of occlusion2022 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） DOI： 10.1152/jn.00301.2022

• 咬合不全が高次脳機能低下を招く神経機構の解明：三叉神経中脳路核周囲の回路網の解析2016 · 2016年4月 - 2019年9月
• 運動野からのトップダウン痛覚抑制機序の解明: 三叉神経痛の治療法開発へ向けて2016 · 2016年4月 - 2020年3月
• 光刺激を用いた入力線維の選択的活性化による運動ニューロン序列動員神経機構の解明2012 · 2012年4月 - 2014年3月
• 光遺伝学的手法を用いた咬筋運動ニューロン興奮性制御におけるTASKの役割の解析2012 · 2012年4月 - 2016年3月

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