Kagoshima University · Graduate School of Medical and Dental Sciences · 助教

Research keywords深層学習・3Dプリンタ・アモルファス・アパタイト・VR・共結晶・バイオマテリアル・ケモメトリックス

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• Preparation and antibacterial evaluation of silver-doped zirconia for enhanced dental restoration performance2024
• Adsorption of oral antibacterial agents on zirconia surfaces with different crystal systems2024
• Otsuka Y., Ben-Nissan B., Kono H., Sasaki T., Kikuchi M. . Mechanochemical synthesis and characterization of strontium substituted apatite for biomedical application . Open Ceramics162023 · 記述言語： 日本語 出版者・発行元： Open Ceramics Strontium-substituted apatite has been proposed as a promising material for osteoporosis treatment. Several synthesis methods have been attempted in the past. In this study, we investigated a method known as the mechanochemical synthesis method. Characterization was carried out using different amounts of strontium ions in the hydroxyapatite (HAp) matrix with FT-IR spectral analysis, X-ray diffraction, lattice constant measurements, differential thermal analysis (DTA), terahertz spectroscopy, and investigation of the basic morphology using scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX). We report that the development and performance of mechanochemical synthetic pathways are more efficient and economical than other substituted apatite formation methods and are useful in the biomedical field to produce calcium phosphate-based clinical materials. The FTIR spectra, terahertz spectra, and XRD analysis results revealed that the mixture of dicalcium phosphate dihydrate (DCPD), Ca(OH)2 and Sr(OH)2 8H2O was phase-transformed into strontium-containing carbonate amorphous apatite by this simple and economical mechanochemical synthesis method. DOI： 10.1016/j.oceram.2023.100459 Scopus
• Kurosawa Y., Otsuka Y., Goto S. . Increased selectivity of sodium deoxycholate to around Tryptophan213 in bovine serum albumin upon micellization as revealed by singular value decomposition fo2022 · 記述言語： 日本語 出版者・発行元： Colloids and Surfaces B: Biointerfaces In the present study, we investigated the effect of bile salts (sodium deoxycholate, NaDC) on the conformation of a globular protein (bovine serum albumin, BSA). The two Tryptophan (Trp) residues of BSA and the fluorescence energy of NaDC are in a three-way relationship, and singular value decomposition (SVD) was used to separate each element in the fluorescence spectra. SVD was used to separate the elements in the fluorescence spectra. SVD showed that NaDC had a particularly large effect on the microenvironment around Trp213 and that micellar NaDC enhanced the selectivity for Trp213. In addition, the Stern-Volmer plots of the warfarin (WAR) specific domain (domain I) and ketoprofen (KP) specific domain (domain II) in the presence and absence of NaDC showed that the effect of NaDC was selective for domain II, where Trp213 is located. These results indicate that NaDC induces a localized and selective conformational change in BSA, and that the selectivity varies depending on the aggregation state of NaDC. DOI： 10.1016/j.colsurfb.2022.112344 Scopus

• ランタノイドと第四級アミンの錯体形成を応用した抗菌性高透光ジルコニアの開発2025
• 破骨細胞分化抑制剤徐放性炭酸アパタイト/コラーゲンの創製
• 医薬品共結晶の製剤物性向上を目的としたビッグデータ解析と回帰予測に関する研究
• 医薬品情報と分子科学情報に基づく機械学習を用いた深共晶探索法の開発と製剤化

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