Kagoshima University · Graduate School of Medical and Dental Sciences · 教授

Research keywordsmaxillofacial reconstruction・cleft lip palate・artificial bone grafts・craniofacial deformity・mandibular hypoplasia・alveolar ridge augmentation・nasal deformity correction

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• Serizawa Shinki, Tezuka Masahiro, Suzuki Hajime, Kamikuri Yuhei, Kimura Namiko, Kibe Toshiro, Ishihata Kiyohide, Saijo Hideto2025 · 記述言語： 英語 出版者・発行元： John Wiley & Sons Australia, Ltd
• Komatsu Noriko, Kosai Azuma, Sakakibara Ayuko, Saijo Hideto, Hoshi Kazuto, Abe Takahiro2025 · 記述言語： 英語 出版者・発行元： 日本病院歯科口腔外科協議会
• Takami Y., Tomita K., Igarashi K., Kuwahara Y., Kitanaka J., Kitanaka N., Roudkenar M.H., Roushandeh A.M., Saijo H., Kurimasa A., Sato T. . Amoxicillin, a β-lactam antibiotic, enhances cisplat2025 · 記述言語： 日本語 出版者・発行元： Biochemical and Biophysical Research Communications Amoxicillin (AMPC) is a commonly used as an antibiotic. This study showed that AMPC enhanced the anticancer effect of cisplatin by inducing mitochondrial dysfunction. Compared with controls, treatment of cervical cancer (HeLa) and oral squamous cell carcinoma (SAS) cells with 10 μg/mL AMPC significantly increased mitochondrial reactive oxygen species levels, decreased mitochondrial membrane potential, and reduced mitochondrial Fe²⁺ levels. This concentration is equivalent to the maximum blood levels of AMPC used in Helicobacter pylori eradication. The viability of HeLa and SAS cells was significantly reduced when cisplatin was administrated after AMPC; however, this effect was not observed in normal human fibroblast-like lung cells (VA-13) or human periodontal ligament fibroblast (HPLF) cells. AMPC did not enhance the anticancer effect of docetaxel. The AMPC-enhanced anticancer effect of cisplatin was blocked by the iron-chelating agent phenanthroline, indicating that the effect was primarily driven by ferroptosis, an iron-dependent form of cell death. The expression levels of the AMPC transporters PEPT1 and PEPT2 were higher in cancer cells such as HeLa and SAS than in normal cells. This phenomenon facilitates greater AMPC uptake and mitochondrial dysfunction in cancer cells. DOI： 10.1016/j.bbrc.2025.151888 Scopus PubMed
• Kobatake Tetsuya, Miyamoto Yoshiyuki, Fujihara Yuko, Saijo Hideto, Hoshi Kazuto, Hikita Atsuhiko2025 · 記述言語： 英語 出版者・発行元： (一社)日本再生医療学会

• フォーカスド・プロテオーム解析による再生組織成熟シグナルの解明と再生医療への応用
• 高接着特性を活用した骨膜幹細胞の単離・培養法確立と顎骨再建への応用
• 生体イメージングと特異的細胞除去による再生骨成熟過程の解明と体外成熟法の確立
• 歯の移動による骨改造現象におけるヘッジホッグ応答性転写因子Gli1の機能の解明

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