Kagoshima University · Graduate School of Medical and Dental Sciences · 助教

Research keywordsglioblastoma・gastric cancer signaling・FARP1・CDC42 signaling・NTRK fusion・spinal canal stenosis・brain tumor pathology

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• Higa N. . Formin-like 1 (FMNL1) is associated with glioblastoma multiforme mesenchymal subtype and independently predicts poor prognosis . International Journal of Molecular Sciences202024 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： International Journal of Molecular Sciences DOI： 10.3390/ijms20246355 Scopus PubMed
• 黒木 伸一, 大吉 達樹, 比嘉 那優大, 佐藤 雅紀, 駒柵 宗一郎, 時村 洋, 吉本 幸司, 花谷 亮典 . 同胞間で発症し，水頭症と脊髄空洞症を合併した後頭部脳瘤の1例：同胞間発症と水頭症併発の機序 . 小児の脳神経48 ( 3 ) 290 - 2942024 · 記述言語： 日本語 出版者・発行元： 一般社団法人 日本小児神経外科学会 <p>症例は0生日女児．妊娠27週に前頭骨の変形と後頚部腫瘤を指摘された．32週の胎児Magnetic Resonance Imaging（MRI）で後頚部脳瘤を認め，38週に予定帝王切開で出生した．後頚部に長径4 cmの腫瘤を認め，MRIで腫瘤内に頭蓋内から逸脱した組織を認めたことから後頭部脳瘤と診断した．1生日に脳瘤修復術，9生日に髄液漏修復術を施行した．さらに術後3か月後に水頭症に対して脳室-腹腔シャント術を施行した．同胞の姉も脳瘤にて手術歴がある．同胞間脳瘤発症例は少なく，多彩な奇形を呈する本例はまれである．今回，同胞間発症と水頭症併発の2点に着目して考察を加える．</p> DOI： 10.34544/jspn.48.3_290 CiNii Research
• Yamahata H., Ijiri K., Tanabe F., Murasumi K., Nagano Y., Makino R., Higa N., Hanaya R. . Radiological Analysis of Cerebrospinal Fluid Dynamics at the Craniovertebral Junction Using Time-Spati2024 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： World Neurosurgery Objective: Spondylotic changes in the cervical spine cause degeneration, leading to cervical spinal canal stenosis. This stenotic change can affect cerebrospinal fluid (CSF) dynamics by compressing the dural sac and reducing space in the subarachnoid space. We examined CSF dynamics at the craniovertebral junction (CVJ) using time-spatial labeling inversion pulse magnetic resonance imaging (Time-SLIP MRI) in patients with cervical spinal canal stenosis. Methods: The maximum longitudinal movement of the CSF at the CVJ was measured as length of motion (LOM) in the Time-SLIP MRI of 56 patients. The sum of ventral and dorsal LOM was defined as the total LOM. Patients were classified into 3 groups depending on their spinal sagittal magnetic resonance imaging findings: control (n = 27, Kang classification grades 0 and 1), stenosis (n = 14, Kang classification grade 2), and severe stenosis (n = 15, Kang classification grade 3). Results: Time-SLIP MRI revealed pulsatile movement of the CSF at the CVJ. The mean total, ventral, and dorsal LOM was 14.2 ± 9, 8.1 ± 5.7, and 3.8 ± 2.9 mm, respectively. The ventral LOM was significantly larger than the dorsal LOM. The total LOM was significantly smaller in the severe stenosis group (6.1 ± 3.4 mm) than in the control (16.0 ± 8.4 mm) or stenosis (11 ± 5.4 mm) groups (P < 0.001, Kruskal-Wallis H-test). In 5 patients, postoperative total LOM was improved after adequate decompression surgery. Conclusions: This study demonstrates that CSF dynamics at the CVJ are influenced by cervical spinal canal stenosis. Time-SLIP MRI is useful for evaluating CSF dynamics at the CVJ in patients with spinal canal stenosis. DOI： 10.1016/j.wneu.2024.02.020 Scopus PubMed
• Nagano Y., Yamahata H., Makino R., Higa N., Sugata J., Fujio S., Hanaya R. . CT correlation of spinal canal diameter with pedicle size for safer posterior cervical pedicle screw fixation2024 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Surgical Neurology International Background: Utilizing computed tomography (CT) studies, we correlated cervical spinal canal diameters (SCDs) with pedicle size between the C3 and C7 levels to more safely perform posterior cervical surgery. Methods: We retrospectively analyzed CT studies for 71 patients with cranial or spinal disorders and correlated the cervical SCD with the pedicle outer width (POW) between the C3 and C7 levels. Patients were divided into normal (SCD ≥12 mm at any level, n = 30) and stenosis groups (SCD <12 mm at any level, n = 41). Results: C7 exhibited the largest SCD and POW values, while C3 and C4 exhibited the smallest SCD and POW values. Moderate correlations (r = 0.3, P = 0.002) were observed at the C3 and C4 levels but no significant correlations were observed from the C5 to C7 levels. For SCD values, the normal group demonstrated significantly greater values between the C3 and C7 levels versus the stenosis group. For POW values, only the C4 level differed significantly between the two groups (P = 0.014, Mann–Whitney U-test). Conclusion: Preoperative pedicle size evaluation remains an essential manoeuvre before performing cervical C3–C7 pedicle screw placement. In 71 cervical CT studies, we found no consistent correlation between POW and SCD values, indicating that it is difficult to estimate POW values based on spinal canal size. DOI： 10.25259/SNI_590_2024 Scopus PubMed

• HDAC7とNNTの相互作用が膠芽腫悪性化に及ぼす影響の解明ー細胞レベルで探るー2023 · 担当区分： 研究分担者 資金種別： 競争的資金 配分額： 3380000円 （ 直接経費： 2600000円 、 間接経費： 780000円 ）
• 機械学習によるグリオーマの診断・予後バイオマーカーの創出と個別化医療への基盤構築2023 · 担当区分： 研究分担者 資金種別： 競争的資金 配分額： 4680000円 （ 直接経費： 3600000円 、 間接経費： 1080000円 ）
• 膠芽腫におけるEGFR意義不明変異の機能解析2023 · 担当区分： 研究分担者 資金種別： 競争的資金 配分額： 4680000円 （ 直接経費： 3600000円 、 間接経費： 1080000円 ）
• 膠芽腫におけるドライバー遺伝子変異の空間的プロテオミクスへの基盤構築2023 · 担当区分： 研究代表者 資金種別： 競争的資金 配分額： 4810000円 （ 直接経費： 3700000円 、 間接経費： 1110000円 ）

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