Ryugaku Jinja · Professor Archive
Public Professor Archive
Yasuo Suda隅田 泰生
Kagoshima University · Graduate School of Science and Engineering · 教授
- Publications
- 4
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- 4
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- 9
留学
神社Kagoshima University · Graduate School of Science and Engineering · 教授
Research keywordsナノ粒子・センサー・相互作用・チップ・糖鎖・TLR7リガンド・ウイルス検出・金ナノ粒子・アジュバント
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- Liu, J-H., Yang, P-C., Chiu, Y-H., Suda, Y.2026 · 記述言語: 英語 掲載種別: 研究論文(学術雑誌)
- Takahashi Kaori, Arima Eriko, Sawayama Hayate, Suda Atsufumi, Miura Naoki, Shirakata Yoshinori, Ito Satoshi, Suda Yasuo2025 · 記述言語: 英語 出版者・発行元: (公社)日本獣医学会
- Noma Y., Sawayama H., Yamashiro K., Nishi K., Yoshinaga H., Takaoka R., Sugiura T., Sasahira T., Hamada T., Suda Y., Okui T. . Melting curve analyses in the quantitative real-time polymerase c2025 · 記述言語: 日本語 出版者・発行元: Heliyon The early detection and early treatment of oral cancer are of paramount importance for improving the patients' prognoses. Our group previously reported a noninvasive test for oral cancer that uses a commercially available methylation-specific multiple ligation-dependent probe amplification (MS-MLPA) method, focusing on the DNA methylation of cells in gargle fluid. However, the conventional MS-MLPA method is complicated, costly, and thus difficult to use for screening and other health examinations. We therefore sought to develop a simple screening method for the diagnosis of oral cancer by conducting a melting curve analysis in a quantitative real-time polymerase chain reaction (qPCR). The assay was performed by a qPCR of DNA from the gargle fluid of 20 patients with oral cancer and 20 healthy control subjects in the training set. The use of these data for the genes BRCA2, CDH13, and MLH1 provided good diagnostic performance. We also applied the assay to a test set of gargle fluid from 10 patients with oral cancer and 10 control subjects, and the results demonstrated the reproducibility of the diagnostic performance. In light of these findings, we propose that this new method could become a noninvasive and convenient screening tool for the detection of oral cancer. DOI: 10.1016/j.heliyon.2025.e42286 Scopus PubMed
- 隅田 泰生 . 糖鎖ナノテクノロジーを用いた高感度・高精度ウイルス検査 . ファルマシア60 ( 3 ) 214 - 218 2024年 詳細を見る 記述言語: 日本語 出版者・発行元: 公益社団法人 日本薬学会 糖鎖ナ2024 · 記述言語: 日本語 出版者・発行元: 公益社団法人 日本薬学会 糖鎖ナノテクノロジーによって、ウイルスが結合する糖鎖を決定し、その糖鎖を固定化したナノ粒子(SGNP)を製造した。そして、そのSGNPを用いてウイルス粒子を簡便に濃縮精製し、PCR検査に供することよって、高感度でかつ偽陽性判定のない高精度の検査法を確立した。本検査法は体外診断薬として保険適用を受けており、社会実装も達成した。 DOI: 10.14894/faruawpsj.60.3_214 CiNii Research
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