Ryugaku Jinja · Professor Archive
Public Professor Archive
Naoki Miura三浦 直樹
Kagoshima University · Division of Veterinary Medicine, School of Agriculture, Fisheries and Veterinary Medicine · 教授
- Publications
- 4
- Projects
- 4
- Keywords
- 10
留学
神社Kagoshima University · Division of Veterinary Medicine, School of Agriculture, Fisheries and Veterinary Medicine · 教授
Research keywords動物モデル・疾患マーカー・獣医学・炎症・溶連菌感染・感染・動脈硬化・動物の病気・再興感染症・乳腺腫瘍
This is a public-data preview. Personalized fit, contact angles, and saved workflows require sign-in.
- Takahashi Kaori, Arima Eriko, Sawayama Hayate, Suda Atsufumi, Miura Naoki, Shirakata Yoshinori, Ito Satoshi, Suda Yasuo2025 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： (公社)日本獣医学会
- 森脇 恵理沙, 松山 洋, 溝口 菫紫, 三浦 直樹2025 · 記述言語： 日本語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： (一社)日本獣医画像診断学会
- Hashimoto S., Hasan M.D.N., Arif M., Nozaki N., Husna A.A., Furusawa Y., Sogawa T., Takahashi K., Kuramoto T., Noguchi A., Takahashi M., Rahman M.M., Miura N. . Identification of dysregulated2025 · 記述言語： 日本語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Research in Veterinary Science Hepatocellular carcinoma (HCC) is the most common liver tumor in dogs. MicroRNA (miRNA) dysregulation and its clinical significance have been reported in dog and human cancers, including HCC. However, determining the whole miRNA transcriptomic profile is essential for diagnosis and therapeutics. Here, we determined the miRNA transcriptomic profile of canine HCC. First, miRNA expression from three control liver tissues and three canine HCC patients was analyzed via small RNA next-generation sequencing (NGS). After analyzing the sequencing reads, differential miRNA (DEmiRNA) expression was further confirmed in the clinical samples and three HCC cell lines via qRT-PCR. The functional pathways of the DEmiRNAs were analyzed from an experimentally validated human miRNA-target database. Our study revealed 20 upregulated and nine downregulated miRNAs. Among them, 10 miRNAs were further validated by qRT-PCR. qRT-PCR and NGS revealed similar miRNA expression patterns. Furthermore, we investigated the signaling pathways based on the KEGG pathway analysis and performed a functional analysis of the dysregulated miRNAs in canine HCC. The upregulated miRNAs mainly play a role in the p53 and cell cycle pathways and function in DNA damage repair and differentiation. In contrast, the downregulated miRNAs are involved in cancer and cell cycle pathways and mainly function in cell differentiation. Further, these miRNAs may be investigated in light of miRNA-based diagnosis and therapies. DOI： 10.1016/j.rvsc.2025.105903 Scopus PubMed researchmap
- 森脇 恵理沙, 松山 洋, 溝口 菫紫, 三浦 直樹 . CT検査で耳管開放症を認めた犬の1例 . 日本獣医画像診断学会抄録76回 np126 - np126 2025年6月 詳細を見る 記述言語： 日本語 掲載種別： 研究論2025 · 記述言語： 日本語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： (一社)日本獣医画像診断学会
Next stepSign in for fit and contact guidance
Personalized fit, contact angles, and saved workflows require sign-in.
