Kanazawa University · Cancer Research Institute · 特任教授

Research fieldsChemical biology・Immunology・Molecular biology・Cell biology

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• Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.
• The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment.
• The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide.
• An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells.

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