International University of Health and Welfare · Faculty of Pharmaceutical Sciences · 教授

Research keywordsstructural biology・nuclear export・ran gtpase・exportin crm1・x-ray crystallography・protein transport・nucleocytoplasmic trafficking

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• Mechanistic Insights from Structural Analyses of Ran-GTPase-Driven Nuclear Export of Proteins and RNAs
• A 2.1-Å-resolution crystal structure of unliganded CRM1 reveals the mechanism of autoinhibition.
• Structural basis for the higher Ca2+-activation of the regulated actin-activated myosin ATPase observed with Dictyostelium/tetrahymena actin chimeras
• Crystal structure of the Xpo1p nuclear export complex bound to the SxFG/PxFG repeats of the nucleoporin Nup42p

• 核-細胞質間高分子輸送制御による生理機能調節機構の構造生物学的研究
• 核外輸送受容体CRM1の構造動態と機能の関係の解明
• Src Family Kinaseのがんシグナルに対する新規阻害剤の探索
• 細胞骨格関連遺伝子群転写調節因子MALがアクチン動態のセンサーとして機能する機構

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