International University of Health and Welfare · Faculty of Pharmaceutical Sciences · 教授

Research keywordsdrug-induced hepatotoxicity・hepatic steatosis・toxicological biomarkers・lipidomics・DGAT1 inhibitors・diabetic rat models・fructose metabolism・transaminase activity・nonclinical toxicology・drug safety assessment

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• Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats.
• Estimation of potential risk of allyl alcohol induced liver injury in diabetic patients using type 2 diabetes spontaneously diabetic Torii-Leprfa (SDT fatty) rats.
• Impact of microsampling on toxicological evaluation in rodent safety studies.
• Specificity of transaminase activities in the prediction of drug-induced hepatotoxicity.

• 消化器毒性に対する低分子有機酸－鉄イオン構造の影響に関する学際的解析

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