International University of Health and Welfare · Graduate School of Medicine

Research keywordsがん免疫療法・悪性黒色腫TIL療法・制御性T細胞解除・免疫チェックポイント阻害・腫瘍関連マクロファージ・4-1BB共刺激・PD-1/TIGIT共阻害・BRAF阻害薬TLR7アゴニスト併用・腫瘍抗原βカテニン変異・悪性胸膜中皮腫ゲノム解析

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• Development of immunotherapy for pancreatic cancer
• Immunosuppression through constitutively activated NF-κB signalling in human ovarian cancer and its reversal by an NF-κB inhibitor
• T-CELL RECEPTOR USAGE BY MELANOMA-SPECIFIC CLONAL AND HIGHLY OLIGOCLONAL TUMOR-INFILTRATING LYMPHOCYTE LINES
• Quantitative analysis of PRAME for detection of minimal residual disease in leukemia.

• 悪性黒色腫の免疫抑制病態に関与するシグナル系の体系的解明と臨床応用
• マイクロサテライト不安定性大腸癌の変異ペプチドを利用した診断法と免疫療法の開発
• 悪性黒色腫シグナル伝達異常による免疫療法抵抗性の解明と克服法の開発
• 網羅的発現解析で同定した悪性黒色腫高発現遺伝子の病態解析と診断・治療への応用

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