International University of Health and Welfare · Odawara Faculty of Health Sciences, Department of Physical Therapy

Research keywordsGタンパク質共役型受容体・リガンドスクリーニング・細胞応答・GPCR・リガンド結合・苦味受容体・アセチルコリン・ムスカリン受容体

Research fieldsMolecular biology・Functional biochemistry・薬理学・薬系衛生、生物化学

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• Exogenous Type-II Phospholipase A_2 Stimulates Prostaglandin Synthesis in Rat Liver-Derived BRL-3A Cells in the Presence of Tumor Necrosis Factor α
• Analysis of Agonism and Inverse Agonism in Functional Assays with Constitutive Activity: Estimation of Orthosteric Ligand Affinity Constants for Active and Inactive Receptor States
• Analysis of Functional Responses at G Protein-Coupled Receptors: Estimation of Relative Affinity Constants for the Inactive Receptor State
• PARTICIPATION IN CELLULAR PROSTAGLANDIN SYNTHESIS OF TYPE-II PHOSPHOLIPASE-A(2) SECRETED AND ANCHORED ON CELL-SURFACE HEPARAN-SULFATE PROTEOGLYCAN

• 腫瘍形成抑制活性を持つ天然化合物の同定とその作用機構に関する研究
• 7回膜貫通型オーファン受容体を用いた新規生理活性ペプチドの探索、構造と機能の解析
• Gタンパク質共役受容体とG16との融合タンパク質を用いたリガンド探索
• G蛋白質によるアラキドン酸カスケ-ド制御機構の解明

• Official profile