Kawasaki Medical School · Faculty of Medicine / Graduate School of Medicine

Research keywordsALS therapeutics・caveolin-3 deficiency・muscular dystrophy・Alzheimer disease iPSCs・myostatin inhibition・Fisher syndrome

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• Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass.
• Familial amyotrophic lateral sclerosis with widespread vacuolation and hyaline inclusions
• Hereditary sensory ataxic neuropathy associated with proximal muscle weakness in the lower extremities
• A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs)

• Parkinのアポトーシス抑制機能の解析
• TTRアミロイドニューロパチーの発症機序の解明
• 異型トランスサイレチンでのシュワン細胞異常による神経変性機序の研究
• マイオスタチン阻害ペプチドによる筋ジストロフィーとサルコペニア治療法の開発

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