Keio University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 教授

Research keywordsNrf2 signaling・Keap1-Nrf2 inhibitors・Medicinal chemistry・Antiviral agents・Fullerene derivatives・Lung cancer sensitization

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• KMN003 activates Nrf2 via disruption of the Keap1-Nrf2 interaction and p38-dependent transcriptional regulation2026 · Cellular Signalling 137
• Development of Keap1-Nrf2 Protein-protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene-2- acetamide Scaffold, and its Anti-inflammatory Effects2025 · ChemMedChem 20
• Development of a fluorescent-labeled trapping reagent to evaluate the risk posed by acyl-CoA conjugates2023 · Drug Metabolism and Pharmacokinetics 52
• Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease2023 · Bioorganic and Medicinal Chemistry Letters 80

• 細胞内移行型反応性代謝物トラッピング剤の開発2025 · -
• 神経細胞保護効果を有する新規パーキンソン病治療薬の開発2023 · -
• 既存薬を基盤とした臓器標的型プロドラッグの創製2021 · -
• 新型コロナウイルス感染症治療薬を目指した新規フラーレン誘導体の創製2021 · -