Keio University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 教授

Research keywordsmicroglia・Alzheimer's disease・neurodegeneration・motor neurons・TBK1 deficiency・locomotion analysis

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• ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice.2025 · Nat. Commun. 16
• CCN1 derived from vascular endothelial cells impairs cognitive function in Alzheimer’s disease model mice.2025 · J. Pharmacol. Sci. 157
• NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration.2024 · Mol. Brain 17
• Type selective ablation of postnatal slow and fast fatigue-resistant motor neurons in mice induces late onset kinetic and postural tremor following fiber-type transition and myopathy.2024 · Exp. Neurol. 376

• 脳に常在する境界性マクロファージの役割解明とALS治療を目指した実験的介入研究2022 · -
• 神経変性疾患における毒性タンパク質の細胞間伝播とグリアリンパ系の関与2019 · -
• 神経活動による免疫ストーム防御の危機管理システムの解明2016 · -