Keio University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences

Research keywordsphysiologically based pharmacokinetics・biliary secretion・placental transport・fetal drug transfer・OATP2B1・metformin pharmacokinetics

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• Characterizing Apixaban Pharmacokinetics Through Physiologically-Based Pharmacokinetic Modeling: Critical Role of Biliary Secretion and Enterohepatic Circulation in Humans2026 · Cpt Pharmacometrics and Systems Pharmacology 15
• Rat-Specific Expression of Placental MATE1 Contributes to Species Difference in Fetal Transfer of Metformin and 1-Methyl-4-Phenylpyridinium.2025 · Molecular pharmaceutics 22
• Conversion of Olmesartan to Olmesartan Medoxomil, A Prodrug that Improves Intestinal Absorption, Confers Substrate Recognition by OATP2B12024 · Pharmaceutical Research
• Fetal ezrin expression affects macrophages and regulatory T cells in mouse placental decidua2024 · Biochemical and Biophysical Research Communications 735

• Ex vivo-in silicoハイブリッドによるヒト胎児薬物移行の新解析プラットフォーム構築2024 · -
• 輸送分子種差と遊離形濃度に基づくヒト胎児への経胎盤薬物曝露量予測モデルの構築2021 · -
• 胎盤エクソソームのウイルス型膜融合を介した妊婦薬物動態の統合制御2020 · -
• トリプトファンバランスに着目した食事による胎児成長支援戦略の構築2018 · -

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