Keio University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences

Research keywordssingle-molecule transport kinetics・human organic anion-transporting・bevacizumab in japanese cancer・impairment of gating mechanism・molecular dynamics simulation impairment・unstable inward-open conformation

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• Population pharmacokinetic analysis of bevacizumab in Japanese cancer patients with proteinuria: a prospective cohort study2025 · Cancer Chemotherapy and Pharmacology 95
• Stoichiometric transport of estrone 3-sulfate among genetic variants of OATP1A2 and OATP2B1 and structural analysis by molecular dynamics simulation: Impairment of gating mechanism in the unstable inward-open conformation of OATP2B1 (Asp215Val) significantly suppress the transport activity2025 · Drug Metabolism and Disposition 53
• Comparative analysis of the single-molecule transport kinetics of OATP1B1 genetic variants2025 · Journal of Pharmacological Sciences 158
• Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach2023 · Journal of Pharmacological Sciences

• 薬物構造の理解から抗体医薬品の免疫原性要因を探求する2024 · -

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