Keio University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences

Research keywordsprotein-protein interactions・FOXO3a and 14-3-3・Nrf2 signaling・protein binding site similarity・glycan-binding proteins・NMR structural biology

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• KMN003 activates Nrf2 via disruption of the Keap1-Nrf2 interaction and p38-dependent transcriptional regulation2026 · Cellular Signalling 137
• Glycan-binding properties of SARS-CoV-2 spike proteins: interactions with aminoglycoside antibiotics2026 · Scientific Reports 2026年03月
• 14-3-3ζ interacts with DNA-binding domain of FOXO3a and competitively dissociates DNA by dual-motif tethering2026 · Nature Communications 17
• Development of Keap1-Nrf2 Protein–Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene-2-acetamide Scaffold, and its Anti-Inflammatory Effects2025 · ChemMedChem 20

• 疾病の原因となる生体高分子間相互作用の新たな拮抗メカニズムの解明と創薬戦略2024 · -
• B型肝炎ウイルス侵入機構の解明と侵入阻害剤による感染制御2022 · -
• B型肝炎ウイルスの肝細胞侵入・増殖機構の構造基盤と立体構造に基づく創薬2021 · -
• 電位依存性イオンチャネルの機能構造と構造間遷移機構の解析による動作機構解明2021 · -

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