Keio University · Faculty of Medicine / Graduate School of Medicine

Research keywordsmyeloid progenitors・exhausted T cells・CAR-T cell therapy・lymphoid malignancies・IL-6 cytokine receptor・antitumor immunity・COVID-19 vaccination

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• Epigenetic profiles guide improved CRISPR/Cas9-mediated gene knockout in human T cells
• Protocol to measure human IL-6 secretion from CAR T cell-primed macrophage and monocyte lineage cells in vitro and in vivo using humanized mice.
• CD62L expression level determines the cell fate of myeloid progenitors.
• Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells.

• 遺伝子改変により生体内での長期生存能を高めた養子免疫療法の開発2024 · -
• 腫瘍微小環境中の免疫抑制性シグナルを変換する新規CAR-T療法の開発2022 · -
• ヒトにおける好中球特異的前駆細胞の同定および好中球分化メカニズムの解明
• 新規抗体医薬の設計およびCAR-T細胞療法との融合による革新的がん免疫療法の研究開発

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