Keio University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 助教

Research keywordsin vitro-in vivo 補外・PBPKモデル・トランスポーター・薬物動態

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• Characterizing Apixaban Pharmacokinetics Through Physiologically-Based Pharmacokinetic Modeling: Critical Role of Biliary Secretion and Enterohepatic Circulation in Humans2025 · Cpt Pharmacometrics and Systems Pharmacology 15
• Bridging in vitro and clinical data: Experimental insights into the IC50 variability of dolutegravir as an organic cation transporter 2 inhibitor2025 · Drug Metabolism and Disposition 53
• Rat-Specific Expression of Placental MATE1 Contributes to Species Difference in Fetal Transfer of Metformin and 1-Methyl-4-Phenylpyridinium2025 · Molecular Pharmaceutics 22
• Analysis of the Correlation Between Membrane Permeability in RPMI 2650 Cells and Human Nasal Absorption2025 · AAPS Pharmscitech 27

• 生理学的薬物速度論モデルに基づく薬物と内因性リガンドの統合的モデリング2025 · -
• 医薬品開発の第１相臨床試験で薬理標的占有率、薬効用量を推定する新規方法論の確立2022 · -
• 抗がん剤併用時の薬物吸収とIVIVEに関する研究2015 · -

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