Kindai University · Faculty of Pharmaceutical Sciences

Research keywordsmicroRNA regulation・ARE-binding proteins・CCR4-NOT complex・mRNA decay・translational repression・pancreatic cancer invasion・PD-L1 dynamics・RNA-binding proteins

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• Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors.
• ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer
• Enhanced Broad-Spectrum Efficacy of an L2-Based mRNA Vaccine Targeting HPV Types 6, 11, 16, 18, with Cross-Protection Against Multiple Additional High-Risk Types.
• Mechanisms of translational regulation by a human eIF5-mimic protein

• 神経特異的RNA結合蛋白質HuDが担う部位特異的翻訳制御機構の解析
• 無細胞in vitro翻訳システムを用いた脱アデニル化複合体によるmRNA分解を介さない翻訳抑制機構の解析
• ヒトGPCR標的RNAアプタマーの創製とその応用による新規腫瘍診断薬の開発

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