Kindai University · Faculty of Medicine · 講師

Research keywords腫瘍生物学・エピジェネティクス・がん幹細胞・TGF-β・ヒストン脱メチル化酵素・CRISPRスクリーニング

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• Vgll2 as an integrative regulator of mitochondrial function and contractility specific to skeletal muscle
• Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)
• Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.
• MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance.

• 脳腫瘍における幹細胞維持機構の解明
• スキルス胃癌の悪性化におけるTGF-βの役割
• エピゲノム制御を介した転移性乳がん発生機構の解明と新規乳がん治療法の開発
• 脳腫瘍がん幹細胞の未分化性の維持機構の遮断とその臨床応用

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