Kindai University · Faculty of Agriculture · 教授

Research keywordsmarine natural products・antifungal potentiators・actinomycete metabolites・sterol O-acyltransferase inhibitors・Candida resistance・microbial secondary metabolites

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• Graphiumins, new thiodiketopiperazines from the marine-derived fungus Graphium sp OPMF00224
• Fungal pyrrolidine-containing metabolites inhibit alkaline phosphatase activity in bone morphogenetic protein-stimulated myoblastoma cells
• Trichocyalides A and B, new inhibitors of alkaline phosphatase activity in bone morphogenetic protein-stimulated myoblasts, produced by Trichoderma sp FKI-5513
• A new ascochlorin derivative from Cylindrocarpon sp. FKI-4602

• Dermcidin を標的とした全く新しい抗メラノーマ薬の開発
• 深海性放線菌が生産する天然物に着目したスキルス胃癌を特異的に排除する抗癌剤の開発
• Dermcidin を標的とした薬剤耐性がんおよび皮膚がん選択的抗がん剤の開発
• メラノーマに対し選択的に活性を示す含硫黄化合物の研究

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