Kindai University · Faculty of Medicine

Research keywords角質細胞間脂質・シグナル情報伝達・Na+/H+交換輸送体・アミノ酸トランスポーター・非特異性多発性小腸潰瘍症・シスチン尿症・タンパク質局在化機構・トランスポーター・細胞極性・脂質代謝

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• Interaction of the sodium/glucose cotransporter (SGLT) 2 inhibitor canagliflozin with SGLT1 and SGLT2: inhibition kinetics, sidedness of action, and transporter-associated incorporation accounting for its pharmacodynamic and pharmacokinetic features
• Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation
• Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.
• Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1

• 大阪大学大学院医学系研究科 動物実験施設運営委員
• 細胞膜ロイシン受容体の分子同定とmTORC1シグナル経路における意義の解明
• がん細胞アミノ酸輸送体阻害薬の強力な細胞周期制御の機序と細胞休眠化機構の解明
• 有機溶質トランスポートソーム:その構築と機能的意義

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