Kitasato University · Graduate School of Engineering for the Future / Faculty of Engineering for the Future · 教授

Research keywordsgenomic profiling・pharmacogenomics・molecular dynamics・drug discovery・next generation sequencing・EGFR mutations・protein interactions・precision oncology

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• Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer.
• Predicting mortality dynamics in cancer patients: A machine learning approach to pre-death events.
• Trp53 Mutation in Keratin 5 (Krt5)-Expressing Basal Cells Facilitates the Development of Basal Squamous-Like Invasive Bladder Cancer in the Chemical Carcinogenesis of Mouse Bladder.
• In silico drug discovery by supercomputer "K".

• 大腸管状腺腫の遺伝子変異プロファイルおよび生物学的多様性についての研究
• 生体分子の動力学計算に対する階層的データマイニングの開拓と薬理の動的機構への応用
• ヒトゲノム構造多型データ類似性検索のための基盤技術開発
• 天然物が織り成す化合物潜在空間が拓く生物活性分子デザイン

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