Kitasato University · Department of Medicine / Faculty of Medicine

Research keywords生理学・膵島β細胞・インスリン分泌・開口放出・2光子励起イメージング

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• Single-molecule analysis of intracellular insulin granule behavior and its application to analyzing cytoskeletal dependence and pathophysiological implications
• Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet
• MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis.
• Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion

• インスリン開口放出準備過程における調節機構の2光子励起解析
• 日本生理学会エデュケーター
• 2光子励起蛍光寿命画像法を用いた膜融合関連蛋白の構造と機能解析
• 2光子励起法で解析する開口放出関連蛋白質の作用機序と糖尿病の病態解明への応用

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