Kitasato University · Department of Medicine / Faculty of Medicine · 講師

Research keywords合成致死・腫瘍生物学・腫瘍治療学・神経芽腫・MYC

This is a public-data preview. Personalized fit, contact angles, and saved workflows require sign-in.

• Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.
• Structural determinant for switching between the polymerase and exonuclease modes in the PCNA-replicative DNA polymerase complex
• Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability
• The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis

• 難治性神経芽腫治療に直結する代謝拮抗剤の利用法とその作用メカニズムの解明
• 発がん初期捕捉に基づく「正常発達逸脱によるがん発生機構」解明
• 細胞分裂期キナーゼ阻害にもとづく難治性神経芽腫の新規治療法開発
• オキサリプラチンによる遺伝子発現調節機構の解明と新規抗癌剤併用療法の研究開発

• Official profile