Kitasato University · Graduate School of Pharmaceutical Sciences / Department of Pharmacy / Faculty of Pharmaceutical Sciences · 助教

Research keywordsPharmacological・Design・Docking・Branched・Biochemistry・Enzyme・Stereochemistry

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• Design and Pharmacological Chaperone Effects of N-(4′-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase2023 · Journal of Medicinal Chemistry
• 5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease2022 · Journal of medicinal chemistry
• Introduction of C-alkyl branches to L-iminosugars changes their active site binding orientation2022 · Organic & Biomolecular Chemistry
• Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity2020 · Molecules

• 変異酵素の立体構造を化学的に操作できるシャペロン化合物の合理的設計と機能解析2024 · 科学研究費助成事業
• 変異酵素の構造安定化に基づく機能性シャペロン化合物の創製とポンペ病治療への応用2021 · 科学研究費助成事業
• 創薬効率を高めるための計算機的フラグメントベース・ドラッグデザイン手法の開発2015 · 科学研究費助成事業
• 計算創薬技術を用いたマクロライド骨格を持つ新規キチナーゼ阻害剤の構造最適化2009 · 科学研究費助成事業

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