Kitasato University · Faculty of Medicine

Research keywords転写因子・糖尿病・膵β細胞・細胞自食・CRISPR-Cas9・MafA・GLP-1・Onecut1

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• Association of soluble CD40 ligand with carotid atherosclerosis in Japanese type 1 diabetic patients
• インスリン転写因子Mafaの新規標的遺伝子に関する検討
• Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis.
• Role of oxidative stress, endoplasmic reticulum stress, and, c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance

• 膵α細胞特異的オートファジー不全マウスの作製とその機能解析
• 膵β細胞ブドウ糖毒性（膵β細胞機能障害）の分子メカニズムの解析
• 膵島不全におけるオートファジーの役割
• New-timerマウスを用いた膵β細胞成熟化機構の解明

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