Kobe University · University Hospital

Research keywordsvolatile anesthetic sedation・sevoflurane in intensive care・remimazolam hemodynamics・postoperative acute kidney injury・syndecan-1 biomarker・off-pump coronary bypass

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• ICUにおけるセボフルランを用いた小児患者の鎮静管理2025 · Japanese Society of Intensive Care Medicine, 2025年12月, 日本集中治療医学会雑誌, 32, n/a - n/a, 日本語
• 人工呼吸管理中の重症COVID-19患者に対するセボフルランの使用経験 ケースシリーズ2024 · (一社)日本集中治療医学会, 2024年01月, 日本集中治療医学会雑誌, 31(1) (1), 9 - 13, 日本語
• Comparison of the Effects of Remimazolam and Sevoflurane on Intraoperative Hemodynamics in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery: A Retrospective Observational Study.2023 · Purpose This study was conducted to compare the efficacy and safety of remimazolam with those of sevoflurane in patients undergoing off-pump coronary artery bypass (OPCAB) surgery. Methods This study was a single-center, retrospective observational study. Adult patients who underwent OPCAB surgery between April 2023 and July 2024 and received sevoflurane or remimazolam for maintenance of general anesthesia were included. The primary outcome was intraoperative average blood pressure (ABP). Secondary outcomes were amounts of norepinephrine and other vasopressors used during surgery, intraoperative heart rate (HR), fluid balance, central venous O2 saturation (SCVO2), score of Intensive Care Delirium Screening Checklist (ICD-SC) during the intensive care unit (ICU) stay, occurrence of postoperative acute kidney injury (AKI) and duration of ICU stay. All postoperative complications during the hospitalization period were evaluated. Results Thirty-six patients were included. Eighteen patients were administered remimazolam and 18 patients were administered sevoflurane for maintenance of general anesthesia. Intraoperative ABP was significantly higher in the remimazolam group than in the sevoflurane group (73±4 mmHg vs 69±6 mmHg, P=0.015). The amount of intraoperative norepinephrine was significantly smaller in the remimazolam group than in the sevoflurane group (910±638 μg vs 2041±927 μg, P
• デスフルラン気化器を用いた全身麻酔中に吸入酸素濃度低下をきたした1例2021 · 日本臨床麻酔学会, 2021年03月, 日本臨床麻酔学会誌, 41(2) (2), 140 - 144, 日本語

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