Kobe University · Research Center for Inland Sea Environmental Education · 教授

Research keywordsバイオアッセイ・環境ホルモン・生態毒性・性分化・性転換・有害化学物質・メダカ・マイクロプラスチック

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• Copper in Commercial Marine Fish: From Biomonitoring to the ESG (Environment, Social, and Governance) Method.2024 · 2024年, Pollutants, 4(1) (1), 117 - 135, 英語
• Non-Phthalate Plasticizer Bis(2-ethylhexyl) Sebacate Induces Testis-Ova Formation and Suppresses Reproduction in Japanese Medaka.2024 · Bis(2-ethylhexyl) sebacate (DEHS), a commonly used non-phthalate plasticizer considered relatively safe relative to phthalates, has been reported to disrupt the endocrine system, affect reproduction-related genes, and potentially induce thyroid hormone-disrupting and estrogenic effects on Japanese medaka (Oryzias latipes). However, the long-term effects of DEHS exposure on aquatic organisms remain unclear; further, data on residual DEHS concentrations in rivers are extremely limited. Here, the effects of DEHS on the reproductive performance and gonadal sex differentiation of Japanese medaka were determined. Japanese medaka embryos and larvae were exposed to varying DEHS concentrations that have been reported to induce thyroid hormone-disrupting effects. The residual concentrations of DEHS in the Sumiyoshi River were measured weekly from May to July in 2024. The formation of testis-ova was induced in XY medaka exposed to varying DEHS concentrations. DEHS exposure was shown to significantly reduce the number of eggs laid but did not affect fertilization rates. The DEHS levels in the Sumiyoshi River were either undetected or below the method quantification limit. Although significant changes in reproductive capacity and testis-ova were not observed at environmentally relevant residual concentrations, this study highlights the potentially harmful effects of a chemical that was previously considered environmentally friendly.
• Seven Epithemia taxa (Bacillariophyta) from Lake Akan (Japan) and their salinity tolerances2023 · 2023年07月, PhytoKeys, 229, 139 - 155, 英語
• Food chain-mediated variation in excretion times of microplastics: Unraveling the interactions with plasticizers2023 · Elsevier BV, 2023年12月, Regional Studies in Marine Science, 103343 - 103343

• 海洋由来模擬二次マイクロプラスチックが魚類に与える生態影響の解明 ―化学的特性との関係性― 堀江好文 日化協 LRI, 2026年03月 - 2029年02月2026 · KUID parsed section
• 化学物質の有害性を予測・毒性評価する新規バイオマーカーの探索とその応用 堀江 好文 日本学術振興会, 科学研究費助成事業, 基盤研究(B), 神戸大学, 2024年04月01日 - 2028年03月31日2024 · KUID parsed section
• メダカを用いた甲状腺ホルモンかく乱物質の検出試験法の開発 堀江好文 独立行政法人環境再生保全機構 環境研究総合推進費, 2023年04月 - 2026年03月, 研究代表者2023 · KUID parsed section
• 閉鎖性海域 大阪湾を モデルケースにしたMPの生態リスク評価 堀江好文 日化協, LRI, 2023年03月 - 2026年02月2023 · KUID parsed section

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