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Research keywordsせん妄・カフェイン・脳波測定・行動実験・低活動型せん妄・術後せん妄

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• Serum sodium measurements in postoperative critically ill patients: The difference between direct and indirect methods2021 · Elsevier Inc., 2021年12月, Perioperative Care and Operating Room Management, 25, 英語
• Reply from authors: The association of intraoperative end-tidal carbon dioxide with the risk of postoperative nausea and vomiting.2020 · 2020年04月, Journal of anesthesia, 34(2) (2), 316 - 316, 英語, 国内誌
• Incidence of hyponatremia with different postoperative intravenous maintenance fluids: a single-center, prospective, randomized trial.2018 · PURPOSE: Patients undergoing surgery are prone to postoperative hyponatremia, which can lead to delirium. However, the optimal sodium concentration for postoperative maintenance fluids in adult patients is still unclear. Therefore, this study examined the incidence of hyponatremia and delirium in postoperative patients. METHODS: This was a single-center, non-blinded, randomized trial. The inclusion criteria for this study were age 20 years or older and elective head and neck cancer or esophageal cancer surgery between April 2018 and June 2023. Patients were randomly assigned to one of three groups based on the sodium concentration in the intravenous fluids administered after surgery: the 140 mmol/L sodium (Na140) group, the 77 mmol/L sodium (Na77) group, and the 35 mmol/L sodium (Na35) group. RESULTS: A total of 105 patients had complete data at the end of the study: Na140 group (n = 35), Na77 group (n = 32), and Na35 group (n = 38). The incidence of postoperative hyponatremia was 22.9% (8/35) in the Na140 group, significantly lower than in the Na77 group [56.3% (18/32)] and the Na35 group [60.5% (23/38)] (both p
• Hemodynamic Changes Following Landiolol Initiation in Patients With Critical Illness Who Developed Tachycardia During Dobutamine Infusion: A Retrospective Observational Study.2014 · Background and objective Dobutamine, a β1-adrenergic agonist, is frequently used to enhance myocardial contractility in patients with critical illness. However, it also increases tachyarrhythmia and myocardial oxygen consumption. Landiolol, an ultra-short-acting and highly β1-selective β-blocker, is used to manage tachycardia in patients with critical illness; however, the combination of a β-agonist and β-blocker seems contradictory at first glance. Previous studies have examined this combination in healthy subjects; however, its effects on patients with critical illness have not been fully elucidated. Hence, this study aimed to address that gap in the literature. Methods This single-center, retrospective, observational study included adult ICU patients who received combination therapy with dobutamine and landiolol between January 1, 2014, and December 31, 2023. Patients who received combination therapy for less than 24 hours or who required extracorporeal circulatory support were excluded. Continuous hemodynamic data were extracted from electronic medical records. Primary outcomes were changes in heart rate (HR) and mean arterial pressure (MAP) after initiation of landiolol administration. Secondary outcomes were achievement of HR

• 画期的な気管挿管器具の開発を目指した研究 大井 まゆ, 溝渕 知司, 中川 桂一, 高野 裕介, 藤本 大地 日本学術振興会, 科学研究費助成事業 挑戦的萌芽研究, 挑戦的萌芽研究, 神戸大学, 2016年04月01日 - 2018年03月31日 既存のMEMSセンサを用い、原理実証試作機を開発した。気管モデルを用いた実験の結果、以下の２点が明らかとなった。すなわち、① 3つのセンサの出力を均一になるようにデバイス先端を屈曲させることで、風上に先端を誘導することができる、② 気道と食道の分岐部ではセンサすべての出力が上昇しその後下降するため、万が一食道挿管が行われた際もセンサの出力が大幅に下がることからすぐに食道挿管と判別することが可能である、であった。①は提案手法のアイディアが実現できることを裏付ける結果であり、②は本デバイスにより気管挿管が安全に行うことができることを示す結果となった。2016 · KUID parsed section
• 画期的な気管挿管器具の開発を目指した研究
• 術後の低活動型せん妄に対するカフェインの治療薬としての有効性の検討
• 慢性高血糖の糖尿病モデルにおける至適な術前血糖管理の開発

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